N-acetyl-D-glucosamine kinase

Details

Name
N-acetyl-D-glucosamine kinase
Synonyms
  • 2.7.1.59
  • GlcNAc kinase
  • N-acetylglucosamine kinase
Gene Name
NAGK
Organism
Humans
Amino acid sequence
>lcl|BSEQ0004446|N-acetyl-D-glucosamine kinase
MAAIYGGVEGGGTRSEVLLVSEDGKILAEADGLSTNHWLIGTDKCVERINEMVNRAKRKA
GVDPLVPLRSLGLSLSGGDQEDAGRILIEELRDRFPYLSESYLITTDAAGSIATATPDGG
VVLISGTGSNCRLINPDGSESGCGGWGHMMGDEGSAYWIAHQAVKIVFDSIDNLEAAPHD
IGYVKQAMFHYFQVPDRLGILTHLYRDFDKCRFAGFCRKIAEGAQQGDPLSRYIFRKAGE
MLGRHIVAVLPEIDPVLFQGKIGLPILCVGSVWKSWELLKEGFLLALTQGREIQAQNFFS
SFTLMKLRHSSALGGASLGARHIGHLLPMDYSANAIAFYSYTFS
Number of residues
344
Molecular Weight
37375.305
Theoretical pI
6.18
GO Classification
Functions
ATP binding / N-acetylglucosamine kinase activity / N-acylmannosamine kinase activity
Processes
carbohydrate phosphorylation / N-acetylglucosamine metabolic process / N-acetylmannosamine metabolic process / N-acetylneuraminate catabolic process
Components
extracellular exosome
General Function
N-acylmannosamine kinase activity
Specific Function
Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0016735|N-acetyl-D-glucosamine kinase (NAGK)
ATGCGCACGCGCACAGGGAGTCAGCTGGCTGCGCGGGAGGTCACGGGAAGTGGGGCGGTG
CCCAGACAGCTGGAGGGAAGGAGGTGTCAGGCGGGGAGAGACGCAAACGGCGGGACCAGC
AGCGACGGTAGCAGCAGCATGGCCGCGATCTATGGGGGTGTAGAGGGGGGAGGCACACGA
TCCGAGGTCCTTTTAGTCTCAGAGGATGGGAAGATCCTGGCAGAAGCAGATGGACTGAGC
ACAAACCACTGGCTGATCGGGACAGACAAGTGTGTGGAGAGGATCAATGAGATGGTGAAC
AGGGCCAAACGGAAAGCAGGGGTGGATCCTCTGGTACCGCTGCGAAGCTTGGGCCTATCT
CTGAGCGGTGGGGACCAGGAGGACGCGGGGAGGATCCTGATCGAGGAGCTGAGGGACCGA
TTTCCCTACCTGAGTGAAAGCTACTTAATCACCACCGATGCCGCCGGCTCCATCGCCACA
GCTACACCGGATGGTGGAGTTGTGCTCATATCTGGAACAGGCTCCAACTGCAGGCTCATC
AACCCTGATGGCTCCGAGAGTGGCTGCGGCGGCTGGGGCCATATGATGGGTGATGAGGGT
TCAGCCTACTGGATCGCACACCAAGCAGTGAAAATAGTGTTTGACTCCATTGACAACCTA
GAGGCGGCTCCTCATGATATCGGCTACGTCAAACAGGCCATGTTCCACTATTTCCAGGTG
CCAGATCGGCTAGGGATACTCACTCACCTGTATAGGGACTTTGATAAATGCAGGTTTGCT
GGGTTTTGCCGGAAAATTGCAGAAGGTGCTCAGCAGGGAGACCCCCTTTCCCGCTATATC
TTCAGGAAGGCTGGGGAGATGCTGGGCAGACACATCGTAGCAGTGTTGCCCGAGATTGAC
CCGGTCTTGTTCCAGGGCAAGATTGGACTCCCCATCCTGTGCGTGGGCTCTGTGTGGAAG
AGCTGGGAGCTGCTGAAGGAAGGTTTTCTTCTGGCGCTGACCCAGGGCAGAGAGATCCAG
GCTCAGAACTTCTTCTCCAGCTTCACCCTGATGAAGCTGAGGCACTCCTCCGCTCTGGGT
GGGGCCAGCCTAGGGGCCAGGCACATCGGGCACCTCCTCCCCATGGACTATAGCGCCAAT
GCCATTGCCTTCTATTCCTACACCTTTTCCTAG
Chromosome Location
2
Locus
2p13.3
External Identifiers
ResourceLink
UniProtKB IDQ9UJ70
UniProtKB Entry NameNAGK_HUMAN
GenBank Protein ID6491737
GenBank Gene IDAJ242910
GenAtlas IDNAGK
HGNC IDHGNC:17174
General References
  1. Hinderlich S, Berger M, Schwarzkopf M, Effertz K, Reutter W: Molecular cloning and characterization of murine and human N-acetylglucosamine kinase. Eur J Biochem. 2000 Jun;267(11):3301-8. [Article]
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  7. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
  8. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [Article]
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  11. Bergfeld AK, Pearce OM, Diaz SL, Pham T, Varki A: Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. J Biol Chem. 2012 Aug 17;287(34):28865-81. doi: 10.1074/jbc.M112.363549. Epub 2012 Jun 12. [Article]
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  14. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  15. Weihofen WA, Berger M, Chen H, Saenger W, Hinderlich S: Structures of human N-Acetylglucosamine kinase in two complexes with N-Acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation. J Mol Biol. 2006 Dec 1;364(3):388-99. Epub 2006 Sep 3. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00141N-Acetylglucosamineapproved, investigational, nutraceuticalunknownDetails