Matrix metalloproteinase-17
Details
- Name
- Matrix metalloproteinase-17
- Synonyms
- 3.4.24.-
- Membrane-type matrix metalloproteinase 4
- Membrane-type-4 matrix metalloproteinase
- MMP-17
- MT-MMP 4
- MT4-MMP
- MT4MMP
- MTMMP4
- Gene Name
- MMP17
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037254|Matrix metalloproteinase-17 MRRRAARGPGPPPPGPGLSRLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFG YLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQ ARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAG SAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGM DLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESV SPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRD RHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRP VSDFSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLD DAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQADGSVAAGVDAAE GPRAPPGQHDQSRSEDGYEVCSCTSGASSPPGAPGPLVAATMLLLLPPLSPGALWTAAQA LTL
- Number of residues
- 603
- Molecular Weight
- 66652.23
- Theoretical pI
- 6.55
- GO Classification
- Functionscalcium ion binding / enzyme activator activity / metalloendopeptidase activity / zinc ion bindingProcessespositive regulation of catalytic activityComponentsanchored component of membrane / integral component of plasma membrane / proteinaceous extracellular matrix
- General Function
- Zinc ion binding
- Specific Function
- Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0012570|Matrix metalloproteinase-17 (MMP17) ATGCGGCGCCGCGCAGCCCGGGGACCCGGCCCGCCGCCCCCAGGGCCCGGACTCTCGCGG CTGCCGCTGCCGCTGCTGCTGCTGCTGGCGCTGGGGACCCGCGGGGGCTGCGCCGCGCCC GCACCCGCGCCGCGCGCCGAGGACCTCAGCCTGGGAGTGGAGTGGCTAAGCAGGTTCGGT TACCTGCCCCCGGCTGACCCCACAACAGGGCAGCTGCAGACGCAAGAGGAGCTGTCTAAG GCCATCACAGCCATGCAGCAGTTTGGTGGCCTGGAGGCCACCGGCATCCTGGACGAGGCC ACCCTGGCCCTGATGAAAACCCCACGCTGCTCCCTGCCAGACCTCCCTGTCCTGACCCAG GCTCGCAGGAGACGCCAGGCTCCAGCCCCCACCAAGTGGAACAAGAGGAACCTGTCGTGG AGGGTCCGGACGTTCCCACGGGACTCACCACTGGGGCACGACACGGTGCGTGCACTCATG TACTACGCCCTCAAGGTCTGGAGCGACATTGCGCCCCTGAACTTCCACGAGGTGGCGGGC AGCGCCGCCGACATCCAGATCGACTTCTCCAAGGCCGACCATAACGACGGCTACCCCTTC GACGGCCCCGGCGGCACCGTGGCCCACGCCTTCTTCCCCGGCCACCACCACACCGCCGGG GACACCCACTTTGACGATGACGAGGCCTGGACCTTCCGCTCCTCGGATGCCCACGGGATG GACCTGTTTGCAGTGGCTGTCCACGAGTTTGGCCACGCCATTGGGTTAAGCCATGTGGCC GCTGCACACTCCATCATGCGGCCGTACTACCAGGGCCCGGTGGGTGACCCGCTGCGCTAC GGGCTCCCCTACGAGGACAAGGTGCGCGTCTGGCAGCTGTACGGTGTGCGGGAGTCTGTG TCTCCCACGGCGCAGCCCGAGGAGCCTCCCCTGCTGCCGGAGCCCCCAGACAACCGGTCC AGCGCCCCGCCCAGGAAGGACGTGCCCCACAGATGCAGCACTCACTTTGACGCGGTGGCC CAGATCCGGGGTGAAGCTTTCTTCTTCAAAGGCAAGTACTTCTGGCGGCTGACGCGGGAC CGGCACCTGGTGTCCCTGCAGCCGGCACAGATGCACCGCTTCTGGCGGGGCCTGCCGCTG CACCTGGACAGCGTGGACGCCGTGTACGAGCGCACCAGCGACCACAAGATCGTCTTCTTT AAAGGAGACAGGTACTGGGTGTTCAAGGACAATAACGTAGAGGAAGGATACCCGCGCCCC GTCTCCGACTTCAGCCTCCCGCCTGGCGGCATCGACGCTGCCTTCTCCTGGGCCCACAAT GACAGGACTTATTTCTTTAAGGACCAGCTGTACTGGCGCTACGATGACCACACGAGGCAC ATGGACCCCGGCTACCCCGCCCAGAGCCCCCTGTGGAGGGGTGTCCCCAGCACGCTGGAC GACGCCATGCGCTGGTCCGACGGTGCCTCCTACTTCTTCCGTGGCCAGGAGTACTGGAAA GTGCTGGATGGCGAGCTGGAGGTGGCACCCGGGTACCCACAGTCCACGGCCCGGGACTGG CTGGTGTGTGGAGACTCACAGGCCGATGGATCTGTGGCTGCGGGCGTGGACGCGGCAGAG GGGCCCCGCGCCCCTCCAGGACAACATGACCAGAGCCGCTCGGAGGACGGTTACGAGGTC TGCTCATGCACCTCTGGGGCATCCTCTCCCCCGGGGGCCCCAGGCCCACTGGTGGCTGCC ACCATGCTGCTGCTGCTGCCGCCACTGTCACCAGGCGCCCTGTGGACAGCGGCCCAGGCC CTGACGCTATGA
- Chromosome Location
- 12
- Locus
- 12q24.3
- External Identifiers
Resource Link UniProtKB ID Q9ULZ9 UniProtKB Entry Name MMP17_HUMAN GenBank Protein ID 18413635 GenBank Gene ID AB021225 HGNC ID HGNC:7163 - General References
- Kajita M, Kinoh H, Ito N, Takamura A, Itoh Y, Okada A, Sato H, Seiki M: Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts. FEBS Lett. 1999 Sep 3;457(3):353-6. [Article]
- Puente XS, Pendas AM, Llano E, Velasco G, Lopez-Otin C: Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. Cancer Res. 1996 Mar 1;56(5):944-9. [Article]
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- Wang Y, Johnson AR, Ye QZ, Dyer RD: Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain. J Biol Chem. 1999 Nov 12;274(46):33043-9. [Article]
- Itoh Y, Kajita M, Kinoh H, Mori H, Okada A, Seiki M: Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase. J Biol Chem. 1999 Nov 26;274(48):34260-6. [Article]
- Kolkenbrock H, Essers L, Ulbrich N, Will H: Biochemical characterization of the catalytic domain of membrane-type 4 matrix metalloproteinase. Biol Chem. 1999 Sep;380(9):1103-8. [Article]