Solute carrier family 22 member 21
Details
- Name
- Solute carrier family 22 member 21
- Synonyms
- Octn3
- Organic cation/carnitine transporter 3
- Slc22a9
- Solute carrier family 22 member 9
- Gene Name
- Slc22a21
- Organism
- Mouse
- Amino acid sequence
>lcl|BSEQ0013317|Solute carrier family 22 member 21 MLDYDEVTAFLGEWGTFQRLIFFLLSASIIPNGFTGLSAVFLTAIPEHRCRIPDTVNLSS AWRNHSIPMETKDGPEVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQENCLDGWEYD KDIFLSTIVTEWDLVCKDDWKAPLTTSFFYVGVLLGSFISGQLSDRFGRKNILFLTMAMH TGFSFIQVFSVNFEMFTLLYTLVGMGHISNYVAAFVLGTEMLSKSVRIIFATLGVCIFFA FGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKA AKINGIVAPSTIFDPSETNKLQDDSSKKPQSHHIYDLVRTPNIRILTIMSIILWLTISVG YFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLV QLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILS PYFVYLGAYDRRLPYILMGSLTILTAIITLFFPESSGVSLPETIDEMQKVKKLKQRQSLS KKGSPKESKGNVSRTSRTSEPKGF
- Number of residues
- 564
- Molecular Weight
- 63320.215
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / carnitine transmembrane transporter activity / cationProcessescarnitine metabolic process / carnitine transmembrane transport / carnitine transport / cation transmembrane transportComponentsintegral component of plasma membrane / intrinsic component of peroxisomal membrane / peroxisome
- General Function
- Cation:cation antiporter activity
- Specific Function
- Sodium-ion independent, medium affinity carnitine transporter. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 746.
- Pfam Domain Function
- Sugar_tr (PF00083)
- Transmembrane Regions
- 21-41 143-163 173-193 198-218 233-253 258-278 345-365 377-397 410-430 434-454 466-486 492-512
- Cellular Location
- Peroxisome membrane
- Gene sequence
>lcl|BSEQ0013318|Solute carrier family 22 member 21 (Slc22a21) ATGCTTGACTACGACGAGGTGACCGCCTTCCTGGGCGAGTGGGGGACCTTCCAGCGCCTC ATCTTCTTCCTGCTCAGCGCCAGCATCATCCCCAATGGCTTTACTGGGTTGTCAGCCGTG TTCCTGACGGCGATCCCGGAGCACCGTTGCCGGATACCAGACACCGTGAACCTGAGCAGC GCGTGGCGCAACCACAGTATCCCGATGGAGACGAAGGACGGACCAGAGGTGCCTCAGAAA TGCCGCCGCTACCGACTGGCCACCATCGCCAACTTCTCTGAGCTAGGGCTGGAGCCGGGA CGGGACGTGGACCTGGAGCAGCTGGAGCAGGAGAACTGCCTGGATGGCTGGGAGTACGAC AAGGACATCTTCCTGTCCACCATCGTGACAGAGTGGGACCTGGTGTGTAAGGATGACTGG AAAGCCCCACTCACCACCTCCTTCTTTTACGTGGGTGTGCTCTTAGGCTCCTTCATTTCG GGACAGCTCTCAGACAGGTTTGGTCGCAAGAATATCTTGTTTTTGACCATGGCCATGCAC ACCGGATTCAGCTTCATACAAGTCTTCTCTGTGAACTTCGAGATGTTTACTCTGCTCTAT ACCCTTGTTGGAATGGGACATATATCCAACTACGTGGCAGCATTTGTCCTGGGAACAGAA ATGCTTTCCAAGTCAGTTAGAATTATATTCGCCACCTTAGGAGTTTGCATATTTTTTGCG TTTGGCTTCATGGTGCTGCCTCTGTTTGCATACTTCATCAGAGAGTGGAGGAGGCTGCTG CTGGCAATTACTTTACCAGGCGTGCTGTGTGGGGCTCTCTGGTGGTTCATCCCTGAGTCC CCACGATGGCTCATCTCTCAAGGCCGAATTAAAGAGGCAGAGGTGATCATCCGCAAAGCT GCCAAAATCAATGGGATTGTTGCACCTTCCACTATCTTCGATCCAAGCGAGACCAATAAA TTACAAGACGATAGTTCCAAGAAGCCCCAGTCGCACCACATTTATGATCTGGTCCGAACA CCAAATATCAGGATCCTCACCATCATGTCTATAATCCTGTGGCTGACCATATCAGTGGGC TATTTTGGACTATCTCTTGACACTCCTAACTTGAATGGGAACATCTATGTGAACTGCTTC CTACTGGCGGCTGTTGAAGTCCCAGCCTATGTGCTGGCCTGGCTGTTGTTGCAGCATGTG TCCCGGCGTTATTCTATGGCTGGTTCCCTCTTCCTGGGTGGCAGTGTCCTTCTCTTAGTA CAACTGGTGCCTTCAGACCTACATTACTTGTCTACTACCCTGGTGATGGTGGGGAAGTTT GGAATCACCTCTGCCTACTCCATGGTCTATGTGTACACAGCTGAGCTGTACCCCACTGTG GTCAGAAACATGGGTGTGGGGGTCAGCTCCACAGCATCCCGCCTTGGCAGCATCCTGTCT CCCTACTTTGTTTATCTAGGTGCCTATGACCGCCGCCTACCTTATATCCTCATGGGAAGT CTAACCATCCTGACAGCTATCATCACTTTATTCTTCCCAGAGAGTTCTGGGGTTTCTCTC CCAGAAACCATTGACGAGATGCAAAAAGTCAAAAAACTAAAACAAAGGCAATCCCTAAGC AAGAAAGGGTCCCCGAAGGAGTCTAAAGGAAATGTATCCCGAACCTCCCGAACCTCCGAA CCTAAAGGCTTTTAA
- Chromosome Location
- 11
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9WTN6 UniProtKB Entry Name S22AL_MOUSE - General References
- Tamai I, Ohashi R, Nezu JI, Sai Y, Kobayashi D, Oku A, Shimane M, Tsuji A: Molecular and functional characterization of organic cation/carnitine transporter family in mice. J Biol Chem. 2000 Dec 22;275(51):40064-72. [Article]
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- Lamhonwah AM, Skaug J, Scherer SW, Tein I: A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn's disease locus (IBD5). Biochem Biophys Res Commun. 2003 Jan 31;301(1):98-101. [Article]
- Lamhonwah AM, Ackerley CA, Tilups A, Edwards VD, Wanders RJ, Tein I: OCTN3 is a mammalian peroxisomal membrane carnitine transporter. Biochem Biophys Res Commun. 2005 Dec 30;338(4):1966-72. Epub 2005 Nov 10. [Article]