Solute carrier family 22 member 21

Details

Name
Solute carrier family 22 member 21
Synonyms
  • Octn3
  • Organic cation/carnitine transporter 3
  • Slc22a9
  • Solute carrier family 22 member 9
Gene Name
Slc22a21
Organism
Mouse
Amino acid sequence
>lcl|BSEQ0013317|Solute carrier family 22 member 21
MLDYDEVTAFLGEWGTFQRLIFFLLSASIIPNGFTGLSAVFLTAIPEHRCRIPDTVNLSS
AWRNHSIPMETKDGPEVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQENCLDGWEYD
KDIFLSTIVTEWDLVCKDDWKAPLTTSFFYVGVLLGSFISGQLSDRFGRKNILFLTMAMH
TGFSFIQVFSVNFEMFTLLYTLVGMGHISNYVAAFVLGTEMLSKSVRIIFATLGVCIFFA
FGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKA
AKINGIVAPSTIFDPSETNKLQDDSSKKPQSHHIYDLVRTPNIRILTIMSIILWLTISVG
YFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLV
QLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILS
PYFVYLGAYDRRLPYILMGSLTILTAIITLFFPESSGVSLPETIDEMQKVKKLKQRQSLS
KKGSPKESKGNVSRTSRTSEPKGF
Number of residues
564
Molecular Weight
63320.215
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / carnitine transmembrane transporter activity / cation
Processes
carnitine metabolic process / carnitine transmembrane transport / carnitine transport / cation transmembrane transport
Components
integral component of plasma membrane / intrinsic component of peroxisomal membrane / peroxisome
General Function
Cation:cation antiporter activity
Specific Function
Sodium-ion independent, medium affinity carnitine transporter. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 746.
Pfam Domain Function
Transmembrane Regions
21-41 143-163 173-193 198-218 233-253 258-278 345-365 377-397 410-430 434-454 466-486 492-512
Cellular Location
Peroxisome membrane
Gene sequence
>lcl|BSEQ0013318|Solute carrier family 22 member 21 (Slc22a21)
ATGCTTGACTACGACGAGGTGACCGCCTTCCTGGGCGAGTGGGGGACCTTCCAGCGCCTC
ATCTTCTTCCTGCTCAGCGCCAGCATCATCCCCAATGGCTTTACTGGGTTGTCAGCCGTG
TTCCTGACGGCGATCCCGGAGCACCGTTGCCGGATACCAGACACCGTGAACCTGAGCAGC
GCGTGGCGCAACCACAGTATCCCGATGGAGACGAAGGACGGACCAGAGGTGCCTCAGAAA
TGCCGCCGCTACCGACTGGCCACCATCGCCAACTTCTCTGAGCTAGGGCTGGAGCCGGGA
CGGGACGTGGACCTGGAGCAGCTGGAGCAGGAGAACTGCCTGGATGGCTGGGAGTACGAC
AAGGACATCTTCCTGTCCACCATCGTGACAGAGTGGGACCTGGTGTGTAAGGATGACTGG
AAAGCCCCACTCACCACCTCCTTCTTTTACGTGGGTGTGCTCTTAGGCTCCTTCATTTCG
GGACAGCTCTCAGACAGGTTTGGTCGCAAGAATATCTTGTTTTTGACCATGGCCATGCAC
ACCGGATTCAGCTTCATACAAGTCTTCTCTGTGAACTTCGAGATGTTTACTCTGCTCTAT
ACCCTTGTTGGAATGGGACATATATCCAACTACGTGGCAGCATTTGTCCTGGGAACAGAA
ATGCTTTCCAAGTCAGTTAGAATTATATTCGCCACCTTAGGAGTTTGCATATTTTTTGCG
TTTGGCTTCATGGTGCTGCCTCTGTTTGCATACTTCATCAGAGAGTGGAGGAGGCTGCTG
CTGGCAATTACTTTACCAGGCGTGCTGTGTGGGGCTCTCTGGTGGTTCATCCCTGAGTCC
CCACGATGGCTCATCTCTCAAGGCCGAATTAAAGAGGCAGAGGTGATCATCCGCAAAGCT
GCCAAAATCAATGGGATTGTTGCACCTTCCACTATCTTCGATCCAAGCGAGACCAATAAA
TTACAAGACGATAGTTCCAAGAAGCCCCAGTCGCACCACATTTATGATCTGGTCCGAACA
CCAAATATCAGGATCCTCACCATCATGTCTATAATCCTGTGGCTGACCATATCAGTGGGC
TATTTTGGACTATCTCTTGACACTCCTAACTTGAATGGGAACATCTATGTGAACTGCTTC
CTACTGGCGGCTGTTGAAGTCCCAGCCTATGTGCTGGCCTGGCTGTTGTTGCAGCATGTG
TCCCGGCGTTATTCTATGGCTGGTTCCCTCTTCCTGGGTGGCAGTGTCCTTCTCTTAGTA
CAACTGGTGCCTTCAGACCTACATTACTTGTCTACTACCCTGGTGATGGTGGGGAAGTTT
GGAATCACCTCTGCCTACTCCATGGTCTATGTGTACACAGCTGAGCTGTACCCCACTGTG
GTCAGAAACATGGGTGTGGGGGTCAGCTCCACAGCATCCCGCCTTGGCAGCATCCTGTCT
CCCTACTTTGTTTATCTAGGTGCCTATGACCGCCGCCTACCTTATATCCTCATGGGAAGT
CTAACCATCCTGACAGCTATCATCACTTTATTCTTCCCAGAGAGTTCTGGGGTTTCTCTC
CCAGAAACCATTGACGAGATGCAAAAAGTCAAAAAACTAAAACAAAGGCAATCCCTAAGC
AAGAAAGGGTCCCCGAAGGAGTCTAAAGGAAATGTATCCCGAACCTCCCGAACCTCCGAA
CCTAAAGGCTTTTAA
Chromosome Location
11
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9WTN6
UniProtKB Entry NameS22AL_MOUSE
General References
  1. Tamai I, Ohashi R, Nezu JI, Sai Y, Kobayashi D, Oku A, Shimane M, Tsuji A: Molecular and functional characterization of organic cation/carnitine transporter family in mice. J Biol Chem. 2000 Dec 22;275(51):40064-72. [Article]
  2. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y: The transcriptional landscape of the mammalian genome. Science. 2005 Sep 2;309(5740):1559-63. [Article]
  3. Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP: Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. 2009 May 5;7(5):e1000112. doi: 10.1371/journal.pbio.1000112. Epub 2009 May 26. [Article]
  4. Lamhonwah AM, Skaug J, Scherer SW, Tein I: A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn's disease locus (IBD5). Biochem Biophys Res Commun. 2003 Jan 31;301(1):98-101. [Article]
  5. Lamhonwah AM, Ackerley CA, Tilups A, Edwards VD, Wanders RJ, Tein I: OCTN3 is a mammalian peroxisomal membrane carnitine transporter. Biochem Biophys Res Commun. 2005 Dec 30;338(4):1966-72. Epub 2005 Nov 10. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB08842Acetylcarnitineapproved, investigationalunknownsubstrateDetails