Uracil phosphoribosyltransferase

Details

Name
Uracil phosphoribosyltransferase
Synonyms
  • 2.4.2.9
  • UMP pyrophosphorylase
  • UPRTase
Gene Name
upp
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Amino acid sequence
>lcl|BSEQ0011423|Uracil phosphoribosyltransferase
MKNLVVVDHPLIKHKLTIMRDKNTGPKEFRELLREITLLLAYEATRHLKCEEVEVETPIT
KTIGYRINDKDIVVVPILRAGLVMADGILELLPNASVGHIGIYRDPETLQAVEYYAKLPP
LNDDKEVFLLDPMLATGVSSIKAIEILKENGAKKITLVALIAAPEGVEAVEKKYEDVKIY
VAALDERLNDHGYIIPGLGDAGDRLFRTK
Number of residues
209
Molecular Weight
23320.02
Theoretical pI
5.7
GO Classification
Functions
GTP binding / magnesium ion binding / uracil phosphoribosyltransferase activity
Processes
UMP salvage / uracil salvage
General Function
Uracil phosphoribosyltransferase activity
Specific Function
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011424|Uracil phosphoribosyltransferase (upp)
ATGAAGAATCTCGTTGTGGTGGATCATCCCCTCATAAAGCACAAACTCACGATCATGAGA
GACAAGAACACCGGTCCGAAGGAGTTCAGAGAGCTGCTCAGAGAGATAACACTCCTCCTC
GCGTACGAAGCCACGAGACATTTGAAGTGCGAGGAAGTAGAGGTGGAAACTCCCATAACG
AAAACGATCGGATACCGTATAAACGATAAGGATATCGTGGTGGTTCCTATTCTCAGAGCC
GGTCTTGTGATGGCGGATGGTATTCTTGAACTGCTTCCAAACGCATCGGTGGGCCACATA
GGAATATACAGAGATCCGGAGACACTTCAAGCGGTGGAATACTACGCCAAGCTGCCTCCT
CTCAACGACGACAAAGAGGTCTTTTTGCTGGATCCCATGCTGGCGACGGGTGTTTCTTCG
ATAAAGGCCATCGAGATTTTGAAGGAGAACGGGGCGAAGAAGATCACGCTGGTGGCTCTG
ATCGCGGCTCCAGAGGGAGTGGAAGCGGTGGAGAAAAAATACGAAGATGTTAAAATCTAC
GTTGCAGCACTGGACGAGCGCCTCAACGATCACGGTTACATCATTCCTGGTCTTGGAGAT
GCGGGTGACAGACTCTTCAGGACAAAATAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9WZI0
UniProtKB Entry NameUPP_THEMA
GenBank Protein ID4981245
GenBank Gene IDAE000512
General References
  1. Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03685Uridine monophosphateexperimentalunknownDetails