5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Details
- Name
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Synonyms
- 2.1.1.14
- Cobalamin-independent methionine synthase
- Methionine synthase, vitamin-B12 independent isozyme
- Gene Name
- metE
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Amino acid sequence
>lcl|BSEQ0016499|5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MKAYAFGFPKIGEKREFKKALEDFWKGKITEEQFEEEMNKLRMYMVENYRKNVDVIPSNE LSYYDFVLDTAVMVGAVPERFGEYRGLSTYFDMARGGKALEMTKFFNTNYHYLVPEIETE EFYLLENKPLEDYLFFKSKGIETAPWVIGPFTFLYLSKRNGEWIRRPNQMEKLLESLVSV YKEVFEKLVENGCKEILVNEPAFVCDLEKAHWDLILNVYRELSEFPLTVFTYYDSVSDYE ACVSLPVKRLHFDFVSNEENLKNLEKHGFPEDKKLVAGVINGRQPWKVDLRKVASLVEKL GASAISNSCPLFHLPVTLELENNLPGGLKEKLAFAKEKLEELKMLKDFLEGKTFDLPNVS FEDFAVDLQAVERVRNLPEDSFRREKEYTERDRIQRERLNLPLFPTTTIGSFPQTPEVRK MRSKYRKGEISKEEYEAFIKEQIKKAIELQEEIGLDVLVHGEFERTDMVEFFAEKLNGIA TTQNGWVLSYGSRCYRPPIIYGTVTRPEPMTLKEITYAQSLTEKPVKGMLTGPVTIMSWS YYREDIPEREIAYQIALAINEEVKDLEEAGIKIVQIDEPAFREKAPIKKSKWPEYFEWAI NAFNLAANARPETQIHAHMCYSDFNEIIEYIHQLEFDVISIEASRSKGEIISAFENFKGW IKQIGVGVWDIHSPAVPSINEMREIVERVLRVLPKELIWINPDCGLKTRNWDEVIPSLRN MVALAKEMREKFES
- Number of residues
- 734
- Molecular Weight
- 85570.495
- Theoretical pI
- 4.97
- GO Classification
- Functions5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity / zinc ion bindingProcessesmethionine biosynthetic process
- General Function
- Zinc ion binding
- Specific Function
- Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016500|5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE) TTGAAGGCTTACGCGTTCGGTTTTCCGAAGATAGGAGAAAAGAGGGAATTCAAAAAGGCT CTGGAGGATTTCTGGAAGGGAAAGATCACGGAAGAACAGTTCGAGGAAGAGATGAACAAA CTCAGAATGTACATGGTGGAAAACTACAGAAAGAACGTCGATGTGATTCCTTCAAACGAA CTTTCCTACTACGACTTTGTGCTCGACACAGCGGTGATGGTGGGGGCAGTTCCGGAGAGG TTCGGTGAGTACAGAGGACTTTCAACGTACTTCGATATGGCGCGCGGTGGAAAGGCTCTG GAAATGACCAAATTCTTCAATACCAACTATCACTACCTCGTTCCGGAAATAGAAACCGAA GAGTTCTATCTTCTCGAAAACAAACCTCTTGAGGATTATCTGTTCTTCAAATCGAAGGGA ATAGAAACAGCACCGTGGGTGATAGGTCCTTTCACTTTCCTGTACCTTTCCAAAAGAAAC GGCGAGTGGATCAGAAGACCAAATCAAATGGAAAAACTGCTGGAAAGCCTCGTTTCTGTT TACAAAGAAGTATTCGAAAAGCTCGTGGAAAATGGCTGTAAGGAGATTCTCGTGAACGAA CCCGCTTTCGTCTGCGATCTTGAAAAGGCCCACTGGGATCTGATACTGAACGTGTACCGT GAGCTTTCAGAATTTCCACTGACTGTTTTCACCTATTACGACAGCGTTTCCGACTACGAA GCGTGCGTCTCCCTTCCGGTGAAGAGACTTCACTTCGATTTCGTTTCGAACGAAGAAAAT CTGAAAAATCTCGAAAAACACGGGTTCCCGGAAGACAAAAAACTCGTGGCTGGTGTGATA AACGGCCGCCAGCCCTGGAAAGTGGATCTCAGAAAGGTGGCATCGCTGGTAGAAAAACTC GGTGCGAGTGCCATCTCAAATTCCTGCCCACTCTTTCATCTTCCAGTGACTCTGGAACTG GAAAACAATCTGCCAGGCGGATTGAAGGAAAAACTTGCCTTTGCAAAAGAAAAGCTCGAA GAGCTAAAAATGTTGAAAGATTTCCTGGAAGGCAAAACATTTGACCTTCCTAACGTGTCT TTTGAAGATTTCGCGGTGGACCTCCAAGCTGTTGAGAGGGTAAGAAATCTTCCAGAAGAT TCGTTCAGAAGGGAGAAAGAATACACCGAGCGCGACAGAATCCAAAGAGAAAGACTGAAC CTTCCACTCTTTCCAACAACGACCATTGGCTCTTTCCCGCAGACTCCTGAAGTGAGAAAG ATGAGATCAAAATACAGAAAGGGAGAAATTTCCAAAGAAGAATATGAAGCTTTCATAAAG GAACAGATAAAAAAGGCTATAGAACTTCAGGAAGAAATAGGACTCGACGTTCTTGTGCAC GGTGAGTTTGAAAGAACCGACATGGTTGAGTTCTTCGCTGAGAAGTTGAACGGCATCGCC ACTACTCAGAACGGCTGGGTTCTCTCCTACGGTTCGAGGTGTTATCGCCCACCAATCATA TACGGCACCGTCACACGACCAGAACCCATGACGCTCAAAGAAATCACCTACGCTCAGTCT CTCACGGAAAAGCCCGTCAAAGGAATGCTCACAGGACCCGTCACCATCATGAGCTGGAGC TACTACAGGGAAGACATCCCAGAGAGAGAAATAGCCTACCAGATAGCCCTTGCGATAAAC GAAGAAGTGAAGGATCTGGAAGAGGCGGGAATAAAAATCGTGCAGATCGACGAGCCCGCG TTCAGAGAAAAAGCACCCATCAAAAAGAGTAAATGGCCTGAGTACTTCGAATGGGCGATA AACGCCTTCAACCTGGCGGCCAACGCGAGACCGGAAACACAGATCCACGCCCACATGTGC TACTCGGATTTCAACGAAATAATTGAGTACATCCACCAGCTGGAGTTCGACGTGATCAGC ATTGAGGCTTCGAGGAGTAAAGGTGAGATCATTTCTGCCTTTGAAAATTTCAAGGGATGG ATCAAGCAGATCGGTGTTGGTGTTTGGGACATCCACTCTCCTGCTGTTCCCTCCATCAAC GAAATGAGGGAAATAGTCGAAAGAGTTCTCAGGGTACTGCCTAAGGAGCTGATCTGGATT AATCCCGACTGCGGTCTCAAGACGAGAAACTGGGACGAAGTAATTCCATCGCTCAGAAAC ATGGTAGCGCTTGCAAAGGAGATGAGGGAAAAATTTGAAAGTTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9X112 UniProtKB Entry Name METE_THEMA GenBank Protein ID 4981844 GenBank Gene ID AE000512 - General References
- Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]