GTPase Der
Details
- Name
- GTPase Der
- Synonyms
- engA
- GTP-binding protein EngA
- TmDer
- Gene Name
- der
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Amino acid sequence
>lcl|BSEQ0016581|GTPase Der MATVLIVGRPNVGKSTLFNKLVKKKKAIVEDEEGVTRDPVQDTVEWYGKTFKLVDTCGVF DNPQDIISQKMKEVTLNMIREADLVLFVVDGKRGITKEDESLADFLRKSTVDTILVANKA ENLREFEREVKPELYSLGFGEPIPVSAEHNINLDTLLETIIKKLEEKGLDLESKPEITDA IKVAIVGRPNVGKSTLFNAILNKERALVSPIPGTTRDPVDDEVFIDGRKYVFVDTAGLRR KSRVEPRTVEKYSNYRVVDSIEKADVVVIVLDATQGITRQDQRIAGLVERRGRASVVVFN KWDLVEHREKRYDEFTKLFREKLYFIDYSPLIFTSADKGWNIDRVIDAINLAYASYTTKV PSSAINSALQKVLAFTNLPRGLKIFFGLQVDIKPPTFLFFVNSIEKVKNPQKIFLRKLIR DYVFPFEGSPIFLKFKRSR
- Number of residues
- 439
- Molecular Weight
- 50014.38
- Theoretical pI
- 9.69
- GO Classification
- FunctionsGTP bindingProcessesribosome biogenesis
- General Function
- Gtp binding
- Specific Function
- GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity). Has GTPase activity but no ATPase activity. GTP, GDP, and dGTP but not GMP, ATP, CTP, and UTP compete for GTP binding.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016582|GTPase Der (der) ATGGCGACGGTTCTGATAGTTGGTAGACCAAACGTTGGAAAGTCTACTCTGTTCAACAAG CTGGTAAAGAAGAAAAAGGCTATTGTCGAAGACGAAGAAGGGGTCACCCGTGACCCCGTT CAAGATACTGTAGAGTGGTACGGGAAAACCTTTAAACTCGTGGACACCTGTGGAGTCTTC GACAATCCACAGGACATCATTTCCCAAAAGATGAAGGAAGTTACCCTGAACATGATCAGA GAAGCTGATCTCGTTCTGTTCGTTGTCGATGGAAAAAGAGGAATTACAAAAGAAGACGAA TCGCTTGCCGATTTTCTCAGGAAATCCACCGTTGATACTATCCTTGTGGCGAACAAAGCG GAAAATCTCAGAGAGTTCGAAAGAGAAGTGAAGCCGGAGCTTTACAGTTTAGGATTTGGA GAACCAATACCCGTTTCTGCAGAGCACAACATAAATCTCGATACTCTCCTGGAGACGATC ATCAAAAAGCTCGAAGAAAAAGGGCTGGATTTAGAATCAAAGCCCGAAATCACCGACGCA ATAAAAGTTGCCATCGTTGGCCGACCGAACGTGGGAAAATCCACACTCTTCAACGCTATA TTGAACAAAGAACGAGCTCTTGTGTCACCGATACCTGGAACAACGAGGGATCCCGTTGAC GACGAAGTGTTTATAGACGGAAGAAAATACGTATTCGTTGACACGGCTGGTTTGAGGAGA AAATCCAGGGTCGAACCCAGGACTGTTGAAAAATACAGCAACTACAGGGTTGTGGACAGC ATAGAAAAAGCGGACGTTGTTGTGATAGTTCTTGATGCAACTCAGGGTATCACAAGACAG GACCAGAGAATAGCCGGCCTTGTGGAAAGACGAGGGAGAGCCAGCGTCGTTGTTTTCAAC AAATGGGATCTCGTTGAACACCGTGAAAAAAGGTACGACGAATTCACCAAATTATTCAGA GAGAAGCTCTATTTCATCGATTACAGTCCGCTTATCTTTACCTCCGCTGACAAAGGCTGG AACATAGACAGAGTGATAGACGCTATCAATTTAGCGTACGCTTCTTACACAACGAAAGTG CCGTCCAGTGCCATTAATTCGGCTCTTCAGAAAGTGCTCGCGTTCACGAATCTCCCTCGT GGTCTCAAGATCTTTTTCGGTCTTCAGGTGGACATAAAACCGCCTACTTTTCTCTTCTTT GTGAACAGCATAGAAAAGGTAAAAAATCCACAAAAGATTTTCCTCAGAAAACTGATCAGG GACTACGTTTTTCCGTTCGAGGGATCTCCTATATTCTTGAAGTTCAAGAGGAGCAGGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9X1F8 UniProtKB Entry Name DER_THEMA GenBank Protein ID 4982010 GenBank Gene ID AE000512 - General References
- Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]
- Hwang J, Inouye M: An essential GTPase, der, containing double GTP-binding domains from Escherichia coli and Thermotoga maritima. J Biol Chem. 2001 Aug 17;276(33):31415-21. Epub 2001 May 31. [Article]
- Robinson VL, Hwang J, Fox E, Inouye M, Stock AM: Domain arrangement of Der, a switch protein containing two GTPase domains. Structure. 2002 Dec;10(12):1649-58. [Article]