Penicillin-binding protein 1B
Details
- Name
- Penicillin-binding protein 1B
- Synonyms
- mrcB
- Murein polymerase
- PBP-1b
- Gene Name
- ponB
- Organism
- Pseudomonas aeruginosa
- Amino acid sequence
>lcl|BSEQ0022481|Penicillin-binding protein 1B MTRPRSPRSRNSKARPAPGLNKWLSWALKLGLVGLVLLAGFAIYLDAVVQEKFSGRRWTI PAKVYARPLELFNGLKLSREDFLRELDALGYRREPSVSGPGTVSVAASAVELNTRGFQFY EGAEPAQRVRVRFNGNYVSGLSQANGKELAVARLEPLLIGGLYPAHHEDRILVKLDQVPT YLIDTLVAVEDRDFWNHHGVSLKSVARAVWVNTTAGQLRQGGSTLTQQLVKNFFLSNERS LSRKINEAMMAVLLELHYDKRDILESYLNEVFLGQDGQRAIHGFGLASQYFFSQPLAELK LDQVALLVGMVKGPSYFNPRRYPDRALARRNLVLDVLAEQGVATQQEVDAAKLRPLGVTR QGSMADSSYPAFLDLVKRQLRQDYRDEDLTEEGLRIFTSFDPILQEKAETSVNETLKRLS GRKGVDQVEAAMVVTNPETGEIQALIGSRDPRFAGFNRALDAVRPIGSLIKPAVYLTALE RPSKYTLTTWVQDEPFAVKGQDGQVWRPQNYDRRSHGTIFLYQGLANSYNLSTAKLGLDV GVPNVLQTVARLGINRDWPAYPSMLLGAGSLSPMEVATMYQTIASGGFNTPLRGIRSVLT ADGQPLKRYPFQVEQRFDSGAVYLVQNAMQRVMREGTGRSVYSQLPSSLTLAGKTGTSND SRDSWFSGFGGDLQAVVWLGRDDNGKTPLTGATGALQVWASFMRKAHPQSLEMPMPENVV MAWVDAQTGQGSAADCPNAVQMPYIRGSEPAQGPGCGSQNPAGEVMDWVRGWLN
- Number of residues
- 774
- Molecular Weight
- 85486.615
- Theoretical pI
- 9.57
- GO Classification
- Functionspenicillin binding / peptidase activity / peptidoglycan glycosyltransferase activityProcessescell wall organization / peptidoglycan biosynthetic process / regulation of cell shape / response to antibioticComponentsintegral component of membrane / peptidoglycan-based cell wall
- General Function
- Peptidoglycan glycosyltransferase activity
- Specific Function
- Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
- Pfam Domain Function
- Transmembrane Regions
- 23-45
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0022482|Penicillin-binding protein 1B (ponB) ATGACGCGTCCCCGATCCCCCCGTTCCCGTAACAGCAAAGCACGCCCGGCACCCGGCCTG AACAAATGGCTCAGCTGGGCTCTCAAGCTCGGCCTCGTCGGCCTGGTGCTCCTCGCCGGC TTCGCCATCTATCTCGATGCCGTGGTGCAGGAGAAATTCTCCGGCCGGCGCTGGACCATC CCGGCGAAGGTCTATGCCCGCCCGCTGGAGCTGTTCAACGGCCTGAAGCTGAGCAGGGAA GACTTCCTGCGCGAACTCGACGCCCTCGGCTACCGTCGCGAGCCCAGCGTGAGCGGCCCT GGAACCGTATCGGTGGCGGCCAGCGCGGTCGAACTCAATACCCGTGGCTTCCAGTTCTAC GAAGGCGCGGAACCGGCCCAGCGCGTGCGCGTGCGCTTCAACGGCAACTACGTCAGCGGG CTGAGCCAGGCCAACGGCAAGGAACTGGCGGTGGCGCGCCTTGAGCCGCTGCTGATCGGC GGCTTGTATCCGGCGCACCATGAGGATCGCATCCTGGTCAAGCTCGACCAGGTGCCGACC TACCTGATCGACACCCTGGTCGCGGTCGAGGATCGCGACTTCTGGAACCACCATGGTGTG TCGCTGAAATCCGTGGCGCGGGCGGTGTGGGTCAACACCACGGCCGGCCAGTTGCGCCAG GGCGGCAGCACCCTGACCCAGCAGTTGGTGAAGAACTTCTTCCTGAGCAATGAGCGCAGC CTGAGCCGCAAGATCAACGAAGCGATGATGGCGGTGCTGCTGGAACTGCACTACGACAAG CGCGACATCCTCGAGTCCTATCTCAACGAGGTGTTCCTCGGCCAGGATGGGCAACGAGCG ATCCATGGCTTCGGCCTGGCCAGCCAGTATTTCTTCAGCCAGCCGTTGGCCGAGCTCAAG CTCGACCAGGTGGCGCTGCTGGTCGGCATGGTCAAGGGGCCGTCCTACTTCAACCCGCGG CGTTACCCGGATCGTGCGCTGGCGCGGCGCAACCTGGTGCTCGACGTGCTCGCCGAGCAG GGCGTGGCGACCCAGCAGGAAGTCGACGCCGCCAAGCTGCGCCCGCTCGGCGTGACCCGG CAGGGCAGCATGGCCGACAGCTCCTATCCGGCCTTCCTCGACCTGGTCAAGCGCCAGTTG CGCCAGGACTACCGCGACGAGGACCTGACTGAGGAAGGGCTGCGCATCTTCACCAGCTTC GATCCGATCCTGCAGGAGAAGGCCGAGACCTCCGTCAACGAAACGCTCAAGCGTCTCAGT GGGCGCAAGGGGGTCGACCAGGTCGAGGCGGCGATGGTCGTGACCAATCCGGAAACCGGT GAGATCCAGGCCCTGATCGGCAGTCGCGACCCGCGCTTCGCCGGCTTCAACCGGGCCCTG GACGCGGTGCGGCCGATCGGTTCGCTGATCAAGCCGGCGGTCTACCTGACCGCTCTCGAG CGGCCGAGCAAGTACACCCTGACCACCTGGGTACAGGACGAGCCCTTCGCGGTGAAAGGC CAGGACGGCCAGGTCTGGCGACCGCAGAACTACGACCGGCGCTCGCATGGCACGATCTTC CTGTACCAGGGCCTGGCAAACTCCTACAACCTGTCCACCGCCAAGCTCGGCCTCGACGTC GGTGTGCCCAACGTGCTGCAGACCGTCGCCCGGCTGGGTATCAACCGTGACTGGCCGGCC TATCCGTCGATGCTGCTGGGCGCCGGTTCGCTCAGTCCGATGGAGGTCGCCACCATGTAC CAGACCATCGCCAGCGGCGGCTTCAACACGCCGTTGCGGGGGATCCGCAGCGTCCTCACT GCCGACGGCCAGCCGCTCAAGCGCTATCCGTTCCAGGTCGAACAGCGCTTCGACTCGGGC GCCGTCTACCTGGTGCAGAACGCCATGCAGCGGGTCATGCGCGAAGGCACCGGGCGTTCG GTGTACAGTCAATTGCCGTCGTCGCTGACCCTCGCCGGCAAGACCGGCACCAGCAACGAC TCGCGCGATAGCTGGTTCTCCGGTTTCGGCGGCGACCTCCAGGCTGTGGTCTGGCTCGGT CGCGACGACAACGGCAAGACGCCGCTTACCGGCGCCACCGGTGCCTTGCAGGTGTGGGCC AGCTTCATGCGCAAGGCGCATCCGCAATCGCTGGAAATGCCGATGCCGGAGAACGTGGTG ATGGCCTGGGTCGACGCGCAGACCGGGCAGGGCTCGGCGGCGGATTGCCCGAATGCCGTA CAGATGCCCTATATTCGTGGCAGCGAGCCCGCCCAGGGCCCAGGCTGCGGGAGCCAGAAC CCCGCCGGCGAGGTGATGGACTGGGTACGTGGCTGGCTGAATTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9X6W0 UniProtKB Entry Name Q9X6W0_PSEAI GenBank Protein ID 4887211 GenBank Gene ID AF147449 - General References
- Not Available
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01329 Cefoperazone approved, investigational yes inhibitor Details DB00430 Cefpiramide approved yes inhibitor Details DB09050 Ceftolozane approved, investigational yes inhibitor Details DB14879 Cefiderocol approved, investigational yes inhibitor Details DB01413 Cefepime approved, investigational yes inhibitor Details