tRNA-splicing ligase RtcB homolog

Details

Name
tRNA-splicing ligase RtcB homolog
Synonyms
  • 6.5.1.3
  • C22orf28
Gene Name
RTCB
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009363|tRNA-splicing ligase RtcB homolog
MSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEKLMFEELRNACRGGGVG
GFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAFDMNDPEAVVSPGGVGFDI
NCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMNAKDLEEALEMGVDWSL
REGYAWAEDKEHCEEYGRMLQADPNKVSARAKKRGLPQLGTLGAGNHYAEIQVVDEIFNE
YAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKIIVNDRQLACARIAS
PEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAKVFNTTPDDLDLHVIYDVSHNIAKVEQ
HVVDGKERTLLVHRKGSTRAFPPHHPLIAVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMT
ETFGTTCHGAGRALSRAKSRRNLDFQDVLDKLADMGIAIRVASPKLVMEEAPESYKNVTD
VVNTCHDAGISKKAIKLRPIAVIKG
Number of residues
505
Molecular Weight
55209.95
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / metal ion binding / poly(A) RNA binding / RNA ligase (ATP) activity / vinculin binding
Processes
gene expression / in utero embryonic development / placenta development / tRNA processing / tRNA splicing, via endonucleolytic cleavage and ligation
Components
cytoplasm / endoplasmic reticulum membrane / nuclear envelope / nucleoplasm / nucleus / tRNA-splicing ligase complex
General Function
Vinculin binding
Specific Function
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0021385|tRNA-splicing ligase RtcB homolog (RTCB)
ATGAGTCGCAGCTATAATGATGAGCTGCAGTTCTTGGAGAAGATCAATAAAAACTGCTGG
AGGATCAAGAAGGGCTTCGTGCCCAACATGCAGGTTGAAGGTGTTTTCTATGTGAATGAT
GCTCTGGAGAAATTGATGTTTGAGGAATTAAGGAATGCCTGTCGAGGTGGTGGTGTTGGT
GGCTTCCTGCCAGCCATGAAACAGATTGGCAATGTGGCAGCCCTGCCTGGAATTGTTCAT
CGATCTATTGGGCTTCCTGATGTCCATTCAGGATATGGGTTTGCTATTGGGAACATGGCA
GCCTTTGATATGAATGACCCTGAAGCAGTAGTATCCCCAGGTGGTGTCGGGTTTGACATC
AACTGTGGTGTCCGCTTGCTAAGAACCAATTTAGATGAAAGTGATGTCCAGCCTGTGAAG
GAGCAACTTGCCCAAGCTATGTTTGACCACATTCCTGTTGGGGTGGGGTCAAAAGGTGTC
ATCCCAATGAATGCCAAAGACTTGGAGGAGGCCTTGGAGATGGGGGTGGACTGGTCCTTA
AGAGAAGGGTATGCCTGGGCTGAAGACAAGGAGCACTGCGAGGAGTACGGAAGGATGCTG
CAGGCTGACCCCAATAAAGTTTCTGCAAGGGCGAAGAAAAGAGGCCTTCCTCAGTTGGGG
ACCCTGGGAGCAGGCAACCATTATGCAGAAATCCAGGTTGTGGATGAGATTTTCAATGAG
TATGCTGCTAAAAAAATGGGCATCGACCATAAGGGACAGGTGTGTGTGATGATCCACAGT
GGAAGCAGAGGCTTGGGCCACCAAGTAGCCACAGATGCGCTGGTAGCTATGGAGAAGGCC
ATGAAGAGAGACAAGATTATAGTCAATGATCGGCAGTTGGCTTGTGCTCGAATCGCTTCC
CCAGAGGGTCAAGACTATCTGAAGGGAATGGCAGCTGCTGGGAACTATGCCTGGGTCAAC
CGCTCTTCCATGACCTTCTTAACCCGTCAGGCTTTCGCCAAGGTCTTCAACACAACCCCT
GATGACTTGGACCTACATGTGATCTATGATGTTTCTCACAACATTGCCAAAGTGGAGCAG
CATGTGGTGGACGGAAAGGAACGGACACTGTTAGTACACAGGAAGGGATCCACCCGCGCT
TTCCCTCCTCACCATCCCCTCATTGCTGTTGATTACCAACTCACTGGACAGCCAGTGCTC
ATTGGTGGCACCATGGGAACCTGTAGTTATGTTCTTACTGGCACTGAACAGGGCATGACT
GAGACCTTTGGAACAACCTGTCATGGAGCGGGCCGTGCATTGTCCCGAGCAAAATCTCGA
CGTAATTTAGATTTCCAGGATGTCTTAGACAAATTGGCAGATATGGGAATTGCGATCCGT
GTTGCCTCACCCAAACTGGTTATGGAAGAGGCTCCTGAGTCCTATAAGAATGTGACAGAT
GTGGTAAATACCTGCCATGATGCTGGAATCAGCAAGAAAGCCATTAAACTGAGACCAATT
GCTGTGATCAAAGGATAG
Chromosome Location
22
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9Y3I0
UniProtKB Entry NameRTCB_HUMAN
HGNC IDHGNC:26935
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02772Sucroseapproved, experimental, investigationalunknownDetails