Choline-phosphate cytidylyltransferase B

Details

Synonyms

2.7.7.15
CCT B
CCT-beta
CCTB
CT B
CTP:phosphocholine cytidylyltransferase B
Phosphorylcholine transferase B

Gene Name

PCYT1B

Organism

Humans

Amino acid sequence

>lcl|BSEQ0000986|Choline-phosphate cytidylyltransferase B
MPVVTTDAESETGIPKSLSNEPPSETMEEIEHTCPQPRLTLTAPAPFADETNCQCQAPHE
KLTIAQARLGTPADRPVRVYADGIFDLFHSGHARALMQAKTLFPNSYLLVGVCSDDLTHK
FKGFTVMNEAERYEALRHCRYVDEVIRDAPWTLTPEFLEKHKIDFVAHDDIPYSSAGSDD
VYKHIKEAGMFVPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKRY
RFQNQVDKMKEKVKNVEERSKEFVNRVEEKSHDLIQKWEEKSREFIGNFLELFGPDGAWK
QMFQERSSRMLQALSPKQSPVSSPTRSRSPSRSPSPTFSWLPLKTSPPSSPKAASASISS
MSEGDEDEK

Number of residues

369

Molecular Weight

41939.76

Theoretical pI

6.36

GO Classification

Functions

choline-phosphate cytidylyltransferase activity

Processes

CDP-choline pathway / glycerophospholipid biosynthetic process / ovarian follicle development / phosphatidylcholine biosynthetic process / phospholipid metabolic process / small molecule metabolic process / spermatogenesis

Components

cytoplasm / endoplasmic reticulum membrane

General Function

Choline-phosphate cytidylyltransferase activity

Specific Function

Controls phosphatidylcholine synthesis.

Pfam Domain Function

CTP_transf_like (PF01467)

Transmembrane Regions

Not Available

Cellular Location

Endoplasmic reticulum

Gene sequence

>lcl|BSEQ0010347|Choline-phosphate cytidylyltransferase B (PCYT1B)
ATGGTAGGCCATCAGGAGTGCATCATGGAAGAGGACAATCGCGCTCCCCAATTGTGGCGC
AAGACCCTGACTGCACCTGCCCCATTTGCTGATGAAACCAACTGCCAGTGTCAAGCACCC
CATGAAAAACTGACCATTGCTCAGGCCCGCTTAGGAACACCAGCTGACAGGCCTGTCAGA
GTATACGCCGATGGAATATTTGACCTCTTCCACTCAGGTCATGCAAGAGCCCTTATGCAA
GCAAAAACACTGTTTCCCAACAGCTACTTGTTGGTAGGAGTTTGCAGTGATGATCTCACC
CACAAATTCAAAGGTTTCACCGTGATGAATGAAGCCGAGAGATACGAAGCTCTCAGACAC
TGTCGCTACGTAGACGAAGTTATCAGAGATGCTCCCTGGACACTCACGCCAGAGTTTCTG
GAAAAACACAAGATTGACTTTGTGGCTCATGATGACATTCCGTATTCCTCTGCTGGCTCT
GATGATGTTTACAAGCACATAAAGGAAGCAGGGATGTTCGTTCCAACGCAGAGAACAGAA
GGCATCTCAACATCGGACATCATTACCAGAATTGTTCGTGACTATGATGTTTATGCCCGA
CGTAACCTCCAGAGAGGGTATACAGCCAAGGAACTGAATGTCAGCTTTATAAATGAGAAG
AGGTACCGTTTCCAGAACCAAGTGGACAAAATGAAGGAAAAAGTCAAGAATGTGGAGGAA
AGATCAAAGGAATTTGTGAACAGAGTGGAAGAAAAGAGCCATGATCTAATTCAAAAGTGG
GAAGAGAAGTCAAGGGAATTCATTGGCAACTTCCTAGAACTGTTTGGACCTGATGGAGCA
TGGAAGCAGATGTTCCAGGAGAGGAGCAGCCGGATGCTGCAGGCCTTATCCCCGAAGCAG
AGCCCTGTGAGCAGCCCAACCCGGAGCCGGTCCCCTTCCCGCTCCCCATCGCCCACCTTC
TCATGGCTTCCACTCAAAACCTCACCCCCTTCCTCACCCAAAGCAGCCTCAGCCTCTATC
AGCAGCATGAGCGAGGGGGATGAGGATGAAAAGTAG

Chromosome Location

Locus

Xp22.11

External Identifiers

Resource	Link
UniProtKB ID	Q9Y5K3
UniProtKB Entry Name	PCY1B_HUMAN
GenBank Protein ID	3153239
GenBank Gene ID	AF052510
GenAtlas ID	PCYT1B
HGNC ID	HGNC:8755

General References

Lykidis A, Murti KG, Jackowski S: Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase. J Biol Chem. 1998 May 29;273(22):14022-9. [Article]
Lykidis A, Baburina I, Jackowski S: Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant. J Biol Chem. 1999 Sep 17;274(38):26992-7001. [Article]
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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB00122	Choline	approved, nutraceutical	unknown	product of	Details
DB14006	Choline salicylate	approved, nutraceutical	unknown	product of	Details