NADPH oxidase 1

Details

Name
NADPH oxidase 1
Synonyms
  • 1.-.-.-
  • Mitogenic oxidase 1
  • MOX-1
  • MOX1
  • NADH/NADPH mitogenic oxidase subunit P65-MOX
  • NOH-1
  • NOH1
  • NOX-1
Gene Name
NOX1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009830|NADPH oxidase 1
MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCL
NFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHL
FNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVI
MTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHP
RKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKV
VMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGD
WTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYK
FQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSN
IVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSL
RKCCHRYSSLDPRKVQFYFNKENF
Number of residues
564
Molecular Weight
64870.455
Theoretical pI
Not Available
GO Classification
Functions
metal ion binding / NADP binding / Rac GTPase binding / superoxide-generating NADPH oxidase activity / voltage-gated proton channel activity
Processes
angiogenesis / cell migration / cellular response to hyperoxia / cellular stress response to acidic pH / extracellular matrix organization / hydrogen peroxide metabolic process / inflammatory response / intracellular pH elevation / NADP metabolic process / oxidation-reduction process / oxygen metabolic process / positive regulation of cell proliferation / positive regulation of integrin biosynthetic process / positive regulation of JNK cascade / positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / positive regulation of smooth muscle cell proliferation / positive regulation of vascular endothelial growth factor production / proton transport / regulation of blood pressure / regulation of systemic arterial blood pressure by renin-angiotensin / respiratory burst / signal transduction / small GTPase mediated signal transduction / superoxide anion generation / superoxide metabolic process
Components
cell junction / early endosome / integral component of membrane / invadopodium membrane / NADPH oxidase complex / plasma membrane
General Function
Voltage-gated proton channel activity
Specific Function
NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.
Pfam Domain Function
Transmembrane Regions
10-30 45-72 103-123 169-189 207-227 397-417
Cellular Location
Cell projection
Gene sequence
>lcl|BSEQ0017844|NADPH oxidase 1 (NOX1)
ATGGGAAACTGGGTGGTTAACCACTGGTTTTCAGTTTTGTTTCTGGTTGTTTGGTTAGGG
CTGAATGTTTTCCTGTTTGTGGATGCCTTCCTGAAATATGAGAAGGCCGACAAATACTAC
TACACAAGAAAAATCCTTGGGTTTTGCAGCCGCACACTGAGAAAGCAATTGGATCACAAC
CTCACCTTCCACAAGCTGGTGGCCTATATGATCTGCCTACATACAGCTATTCACATCATT
GCACACCTGTTTAACTTTGACTGCTATAGCAGAAGCCGACAGGCCACAGATGGCTCCCTT
GCCTCCATTCTCTCCAGCCTATCTCATGATGAGAAAAAGGGGGGTTCTTGGCTAAATCCC
ATCCAGTCCCGAAACACGACAGTGGAGTATGTGACATTCACCAGCATTGCTGGTCTCACT
GGAGTGATCATGACAATAGCCTTGATTCTCATGGTAACTTCAGCTACTGAGTTCATCCGG
AGGAGTTATTTTGAAGTCTTCTGGTATACTCACCACCTTTTTATCTTCTATATCCTTGGC
TTAGGGATTCACGGCATTGGTGGAATTGTCCGGGGTCAAACAGAGGAGAGCATGAATGAG
AGTCATCCTCGCAAGTGTGCAGAGTCTTTTGAGATGTGGGATGATCGTGACTCCCACTGT
AGGCGCCCTAAGTTTGAAGGGCATCCCCCTGAGTCTTGGAAGTGGATCCTTGCACCGGTC
ATTCTTTATATCTGTGAAAGGATCCTCCGGTTTTACCGCTCCCAGCAGAAGGTTGTGATT
ACCAAGGTTGTTATGCACCCATCCAAAGTTTTGGAATTGCAGATGAACAAGCGTGGCTTC
AGCATGGAAGTGGGGCAGTATATCTTTGTTAATTGCCCCTCAATCTCTCTCCTGGAATGG
CATCCTTTTACTTTGACCTCTGCTCCAGAGGAAGATTTCTTCTCCATTCATATCCGAGCA
GCAGGGGACTGGACAGAAAATCTCATAAGGGCTTTCGAACAACAATATTCACCAATTCCC
AGGATTGAAGTGGATGGTCCCTTTGGCACAGCCAGTGAGGATGTTTTCCAGTATGAAGTG
GCTGTGCTGGTTGGAGCAGGAATTGGGGTCACCCCCTTTGCTTCTATCTTGAAATCCATC
TGGTACAAATTCCAGTGTGCAGACCACAACCTCAAAACAAAAAAGATCTATTTCTACTGG
ATCTGCAGGGAGACAGGTGCCTTTTCCTGGTTCAACAACCTGTTGACTTCCCTGGAACAG
GAGATGGAGGAATTAGGCAAAGTGGGTTTTCTAAACTACCGTCTCTTCCTCACCGGATGG
GACAGCAATATTGTTGGTCATGCAGCATTAAACTTTGACAAGGCCACTGACATCGTGACA
GGTCTGAAACAGAAAACCTCCTTTGGGAGACCAATGTGGGACAATGAGTTTTCTACAATA
GCTACCTCCCACCCCAAGTCTGTAGTGGGAGTTTTCTTATGTGGCCCTCGGACTTTGGCA
AAGAGCCTGCGCAAATGCTGTCACCGATATTCCAGTCTGGATCCTAGAAAGGTTCAATTC
TACTTCAACAAAGAAAATTTTTGA
Chromosome Location
X
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9Y5S8
UniProtKB Entry NameNOX1_HUMAN
HGNC IDHGNC:7889
General References
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  2. Banfi B, Maturana A, Jaconi S, Arnaudeau S, Laforge T, Sinha B, Ligeti E, Demaurex N, Krause KH: A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1. Science. 2000 Jan 7;287(5450):138-42. [Article]
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  10. Miyano K, Sumimoto H: N-Linked glycosylation of the superoxide-producing NADPH oxidase Nox1. Biochem Biophys Res Commun. 2014 Jan 17;443(3):1060-5. doi: 10.1016/j.bbrc.2013.12.086. Epub 2013 Dec 21. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09140Oxygenapproved, vet_approvedunknownagonistactivatorDetails