Zinc transporter 1
Details
- Name
- Zinc transporter 1
- Synonyms
- Solute carrier family 30 member 1
- ZnT-1
- ZNT1
- Gene Name
- SLC30A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052345|Zinc transporter 1 MGCWGRNRGRLLCMLALTFMFMVLEVVVSRVTSSLAMLSDSFHMLSDVLALVVALVAERF ARRTHATQKNTFGWIRAEVMGALVNAIFLTGLCFAILLEAIERFIEPHEMQQPLVVLGVG VAGLLVNVLGLCLFHHHSGFSQDSGHGHSHGGHGHGHGLPKGPRVKSTRPGSSDINVAPG EQGPDQEETNTLVANTSNSNGLKLDPADPENPRSGDTVEVQVNGNLVREPDHMELEEDRA GQLNMRGVFLHVLGDALGSVIVVVNALVFYFSWKGCSEGDFCVNPCFPDPCKAFVEIINS THASVYEAGPCWVLYLDPTLCVVMVCILLYTTYPLLKESALILLQTVPKQIDIRNLIKEL RNVEGVEEVHELHVWQLAGSRIIATAHIKCEDPTSYMEVAKTIKDVFHNHGIHATTIQPE FASVGSKSSVVPCELACRTQCALKQCCGTLPQAPSGKDAEKTPAVSISCLELSNNLEKKP RRTKAENIPAVVIEIKNMPNKQPESSL
- Number of residues
- 507
- Molecular Weight
- 55299.41
- Theoretical pI
- Not Available
- GO Classification
- Functionscalcium channel inhibitor activity / zinc ion transmembrane transporter activityProcessescadmium ion transmembrane transport / calcium ion import / cellular calcium ion homeostasis / cellular zinc ion homeostasis / detoxification of cadmium ion / in utero embryonic development / negative regulation of calcium ion import / negative regulation of neurotransmitter secretion / negative regulation of zinc ion transmembrane import / zinc ion transportComponentscell / cytoplasm / endoplasmic reticulum / Golgi apparatus / integral component of postsynaptic density membrane / nuclear membrane / plasma membrane / Schaffer collateral - CA1 synapse / T-tubule
- General Function
- May be involved in zinc transport out of the cell.
- Specific Function
- Calcium channel inhibitor activity
- Pfam Domain Function
- Cation_efflux (PF01545)
- Transmembrane Regions
- 11-31 36-56 79-99 114-134 249-269 309-329
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052346|Zinc transporter 1 (SLC30A1) ATGGGGTGTTGGGGTCGGAACCGGGGCCGGCTGCTGTGCATGCTGGCGCTGACCTTCATG TTCATGGTGCTGGAGGTGGTGGTGAGCCGGGTGACCTCGTCGCTGGCGATGCTCTCCGAC TCCTTCCACATGCTGTCGGACGTGCTGGCGCTGGTGGTGGCGCTGGTGGCCGAGCGCTTC GCCCGGCGGACCCACGCCACCCAGAAGAACACGTTCGGCTGGATCCGAGCCGAGGTAATG GGGGCTCTGGTGAACGCCATCTTCCTGACTGGCCTCTGTTTCGCCATCCTGCTGGAGGCC ATCGAGCGCTTCATCGAGCCGCACGAGATGCAGCAGCCGCTGGTGGTCCTTGGGGTCGGC GTGGCCGGGCTGCTGGTCAACGTGCTGGGGCTCTGCCTCTTCCACCATCACAGCGGCTTC AGCCAGGACTCCGGCCACGGCCACTCGCACGGGGGTCACGGCCACGGCCACGGCCTCCCC AAGGGGCCTCGCGTTAAGAGCACCCGCCCCGGGAGCAGCGACATCAACGTGGCCCCGGGC GAGCAGGGTCCCGACCAGGAGGAGACCAACACCCTGGTGGCCAATACCAGCAACTCCAAC GGGCTGAAATTGGACCCCGCAGACCCAGAAAACCCCAGAAGTGGTGATACAGTGGAAGTA CAAGTGAATGGAAATCTTGTCAGAGAACCTGACCATATGGAACTGGAAGAAGATAGGGCT GGACAACTTAACATGCGTGGAGTTTTTCTGCATGTCCTTGGAGATGCCTTGGGTTCAGTG ATTGTAGTAGTAAATGCCTTAGTCTTTTACTTTTCTTGGAAAGGTTGTTCTGAAGGGGAT TTTTGTGTGAATCCATGTTTCCCTGACCCCTGCAAAGCATTTGTAGAAATAATTAATAGT ACTCATGCATCAGTTTATGAGGCTGGTCCTTGCTGGGTGCTATATTTAGATCCAACTCTT TGTGTTGTAATGGTTTGTATACTTCTTTACACAACCTATCCATTACTTAAGGAATCTGCT CTTATTCTTCTACAAACTGTTCCTAAACAAATTGATATCAGAAATTTGATAAAAGAACTT CGAAATGTTGAAGGAGTTGAGGAAGTTCATGAATTACATGTTTGGCAACTTGCTGGAAGC AGAATCATTGCCACTGCTCACATAAAATGTGAAGATCCAACATCATACATGGAGGTGGCT AAAACCATTAAAGACGTTTTTCATAATCACGGAATTCACGCTACTACCATTCAGCCTGAA TTTGCTAGTGTAGGCTCTAAATCAAGTGTAGTTCCGTGTGAACTTGCCTGCAGAACCCAG TGTGCTTTGAAGCAATGTTGTGGGACACTACCACAAGCCCCTTCTGGAAAGGATGCAGAA AAGACCCCAGCAGTTAGCATTTCTTGTTTAGAACTTAGTAACAATCTAGAGAAGAAGCCC AGGAGGACTAAAGCTGAAAACATCCCTGCTGTTGTGATAGAGATTAAAAACATGCCAAAC AAACAACCTGAATCATCTTTGTGA
- Chromosome Location
- 1
- Locus
- 1q32.3
- External Identifiers
Resource Link UniProtKB ID Q9Y6M5 UniProtKB Entry Name ZNT1_HUMAN HGNC ID HGNC:11012 - General References
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [Article]
- Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
- Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570. [Article]
- Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S: Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71. doi: 10.1021/pr300630k. Epub 2012 Dec 18. [Article]