Quinoprotein ethanol dehydrogenase

Details

Name
Quinoprotein ethanol dehydrogenase
Synonyms
  • 1.1.2.8
  • QEDH
Gene Name
exaA
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Amino acid sequence
>lcl|BSEQ0016957|Quinoprotein ethanol dehydrogenase
MTTRTSPAPAGLLRPSLHCLAFAVALGSAGAALAKDVTWEDIANDDKTTGDVLQYGMGTH
AQRWSPLKQVNADNVFKLTPAWSYSFGDEKQRGQESQAIVSDGVIYVTASYSRLFALDAK
TGKRLWTYNHRLPDDIRPCCDVVNRGAAIYGDKVFFGTLDASVVALNKNTGKVVWKKKFA
DHGAGYTMTGAPTIVKDGKTGKVLLIHGSSGDEFGVVGRLFARDPDTGEEIWMRPFVEGH
MGRLNGKDSTVTGDVKAPSWPDDRNSPTGKVESWSHGGGAPWQSASFDAETNTIIVGAGN
PGPWNTWARTAKGGNPHDYDSLYTSGQVGVDPSSGEVKWFYQHTPNDAWDFSGNNELVLF
DYKAKDGKIVKATAHADRNGFFYVVDRSNGKLQNAFPFVDNITWASHIDLKTGRPVEREG
QRPPLPEPGQKHGKAVEVSPPFLGGKNWNPMAYSQDTGLFYVPANHWKEDYWTEEVSYTK
GSAYLGMGFRIKRMYDDHVGSLRAMDPVSGKVVWEHKEHLPLWAGVLATAGNLVFTGTGD
GYFKAFDAKSGKELWKFQTGSGIVSPPITWEQDGEQYLGVTVGYGGAVPLWGGDMADLTR
PVAQGGSFWVFKLPSWDNRTASR
Number of residues
623
Molecular Weight
68122.88
Theoretical pI
7.11
GO Classification
Functions
2-chloroethanol / alcohol dehydrogenase (acceptor) activity / calcium ion binding / ethanol
Processes
ethanol oxidation
Components
membrane / outer membrane-bounded periplasmic space
General Function
Ethanol:cytochrome c oxidoreductase activity
Specific Function
Catalyzes the oxidation of primary alcohols except for methanol that is a very poor substrate.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Periplasm
Gene sequence
>lcl|BSEQ0016958|Quinoprotein ethanol dehydrogenase (exaA)
ATGACAACAAGAACCTCACCCGCCCCTGCCGGCCTCCTGCGCCCGAGCCTGCACTGCCTC
GCCTTCGCCGTCGCCCTGGGCAGCGCTGGCGCCGCGCTGGCCAAGGATGTGACCTGGGAG
GACATCGCCAACGACGACAAGACCACCGGCGACGTGCTGCAGTACGGCATGGGCACCCAC
GCCCAGCGCTGGAGCCCGCTCAAGCAGGTCAACGCCGACAACGTGTTCAAGCTGACCCCG
GCCTGGTCGTACTCCTTCGGCGACGAGAAACAGCGCGGCCAGGAGTCCCAGGCCATCGTC
AGCGACGGCGTGATCTACGTGACCGCCTCCTACTCGCGGCTGTTCGCCCTCGACGCGAAG
ACCGGCAAGCGCCTGTGGACCTACAACCACCGCCTGCCCGACGACATCCGCCCGTGCTGC
GACGTGGTCAACCGCGGCGCCGCGATCTATGGCGACAAGGTGTTCTTCGGCACCCTCGAC
GCCTCGGTGGTGGCGCTGAACAAGAACACCGGCAAGGTGGTGTGGAAGAAGAAGTTCGCC
GATCACGGCGCCGGCTACACCATGACTGGCGCGCCGACCATCGTGAAGGACGGCAAGACC
GGCAAGGTCCTGCTGATCCACGGCAGTTCGGGCGACGAGTTCGGCGTGGTCGGCCGCCTG
TTCGCCCGCGATCCGGATACCGGCGAGGAAATCTGGATGCGTCCCTTCGTCGAAGGCCAC
ATGGGCCGCCTGAACGGCAAGGACAGCACGGTGACCGGCGACGTCAAGGCGCCCTCCTGG
CCGGACGATCGCAACTCGCCGACCGGCAAGGTCGAGTCGTGGAGCCACGGCGGCGGCGCT
CCCTGGCAGAGCGCCAGCTTCGACGCCGAGACCAACACCATCATCGTCGGCGCCGGCAAC
CCCGGCCCGTGGAACACCTGGGCGCGCACCGCCAAGGGCGGCAACCCGCACGACTACGAC
AGCCTCTACACCTCCGGCCAGGTCGGGGTGGACCCGAGCAGCGGCGAGGTGAAGTGGTTC
TACCAGCACACCCCCAACGACGCCTGGGACTTCTCCGGCAACAACGAACTGGTGCTGTTC
GACTACAAGGCCAAGGACGGCAAGATCGTCAAGGCCACCGCCCACGCCGACCGCAACGGC
TTCTTCTATGTGGTCGACCGCAGCAACGGCAAGTTGCAGAACGCCTTCCCCTTCGTCGAC
AACATCACCTGGGCCAGCCACATCGACCTGAAGACCGGCCGCCCGGTGGAGCGCGAGGGC
CAGCGCCCGCCGCTGCCGGAACCGGGGCAGAAGCATGGCAAGGCGGTGGAAGTATCGCCG
CCGTTCCTCGGCGGCAAGAACTGGAACCCGATGGCCTACAGCCAGGACACCGGCCTGTTC
TACGTGCCGGCCAACCACTGGAAGGAAGACTACTGGACCGAGGAGGTCAGCTATACGAAG
GGCAGCGCCTACCTTGGCATGGGCTTCCGGATCAAGCGCATGTACGACGACCACGTCGGC
AGCCTGCGCGCCATGGACCCGGTCAGCGGCAAGGTGGTCTGGGAACACAAGGAACACCTG
CCGCTCTGGGCCGGGGTGCTGGCCACCGCCGGCAACCTGGTGTTCACCGGCACCGGCGAC
GGCTACTTCAAGGCCTTCGACGCGAAGAGCGGCAAGGAGCTGTGGAAATTCCAGACCGGC
AGCGGCATCGTCTCGCCACCGATCACCTGGGAACAGGACGGCGAGCAGTACCTCGGCGTG
ACCGTCGGCTACGGCGGCGCCGTGCCGCTGTGGGGCGGCGACATGGCCGACCTGACCCGG
CCGGTGGCCCAGGGCGGTTCCTTCTGGGTATTCAAGCTGCCCAGCTGGGACAACCGCACC
GCCAGCCGCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9Z4J7
UniProtKB Entry NameEXAA_PSEAE
GenBank Gene IDAJ009858
General References
  1. Diehl A, von Wintzingerode F, Gorisch H: Quinoprotein ethanol dehydrogenase of Pseudomonas aeruginosa is a homodimer--sequence of the gene and deduced structural properties of the enzyme. Eur J Biochem. 1998 Oct 15;257(2):409-19. [Article]
  2. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
  3. Schobert M, Gorisch H: Cytochrome c550 is an essential component of the quinoprotein ethanol oxidation system in Pseudomonas aeruginosa: cloning and sequencing of the genes encoding cytochrome c550 and an adjacent acetaldehyde dehydrogenase. Microbiology. 1999 Feb;145 ( Pt 2):471-81. [Article]
  4. Keitel T, Diehl A, Knaute T, Stezowski JJ, Hohne W, Gorisch H: X-ray structure of the quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa: basis of substrate specificity. J Mol Biol. 2000 Apr 7;297(4):961-74. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03205Pyrroloquinoline QuinoneexperimentalunknownDetails