This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Silicon dioxide is an ingredient found in a variety of supplements and vitamins.
- Brand Names
- Gelusil, Pediacare Gas Relief
- Generic Name
- Silicon dioxide
- DrugBank Accession Number
- DB11132
- Background
Silicon dioxide, or silica, is an oxide of silicon with the chemical formula SiO2. It is found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite as transparent and tasteless crystals. Inhalation of fine crystals is toxic to humans leading to respiratory toxicity. In powdered food products and pharmaceutical tablets, silicon dioxide is added as a flow agent to absorb water. Colloidal silica is also used as a wine, beer, and juice fining agent or stabilizer.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Silicon dioxide (DB11132)
- Weight
- Average: 60.0843
Monoisotopic: 59.966755777 - Chemical Formula
- O2Si
- Synonyms
- Colloidal silica
- Colloidal silicon dioxide
- Diatomaceous earth
- Diatomaceous silica
- Diatomite
- Infusorial earth
- Kieselsäureanhydrid
- Silica
- Silica gel
- Silica, colloidal
- Siliceous earth
- Siliceous earth, purified
- Silicon dioxide (amorphous)
- Silicon dioxide, colloidal
- Silicon dioxide, fumed
- Silicon oxide
- Siliziumdioxid
- External IDs
- E-551
- INS NO.551
- INS-551
- U 333
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UMacrophage receptor MARCO Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 2080 Dentistry Night Fresh Paste, dentifrice 15 g/100g Dental Aekyung Industrial Co., Ltd. 2017-02-03 Not applicable US 
2080 Dentistry Night Repair Paste, dentifrice 15 g/100g Dental Aekyung Industrial Co., Ltd. 2017-02-03 Not applicable US 28tak Doux Tooth Paste, dentifrice 4.8 g/60g Oral Elmeditec Co.,Ltd 2018-07-01 Not applicable US Antiseptic Disinfectant Liquid 0.56 g/100mL Topical Nano Care Deutschland AG 2020-03-28 Not applicable US Chlorine Dioxide Air Sterilization Card Powder 30 g/100g Topical Heyuan City Wingart Enterprises Co., Ltd. 2020-03-30 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 28tak Clair Tooth Silicon dioxide (4.8 g/60g) + Sodium fluorophosphate (0.13 g/60g) Paste, dentifrice Oral Elmeditec Co.,Ltd 2018-07-01 Not applicable US Alegria Neo Silicon dioxide (2.80 g/20g) + Allantoin (0.008 g/20g) Paste, dentifrice Topical Seowangmo Corporation 2017-10-01 Not applicable US BAMBOO SALT Eunganggo Jook Yeom Silicon dioxide (20 g/100g) + Aminocaproic acid (0.05 g/100g) + Curcuma xanthorrhiza oil (0.025 g/100g) + Glycyrrhizinate dipotassium (0.04 g/100g) + Sea salt (3 g/100g) + Sodium fluoride (0.22 g/100g) + Ursodeoxycholic acid (0.02 g/100g) Paste Dental Lg Household & Health Care Ltd. 2011-03-15 Not applicable US BAMBOO SALT Eunganggo Jook Yeom Toothpaste Silicon dioxide (20 g/100g) + Aminocaproic acid (0.05 g/100g) + Curcuma xanthorrhiza oil (0.025 g/100g) + Glycyrrhizinate dipotassium (0.04 g/100g) + Sea salt (3 g/100g) + Sodium fluoride (0.22 g/100g) + Ursodeoxycholic acid (0.02 g/100g) Paste Dental Lg Household & Health Care Ltd. 2010-05-25 Not applicable US Calcium and Magnesium 1:1 Plus Tablets Silicon dioxide (5 mg) + Calcium (250 mg) + Cholecalciferol (100 unit) + Magnesium (250 mg) + Manganese (1 mg) + Potassium (20 mg) + Zinc (5 mg) Tablet Oral Albi Naturals 1998-02-20 2009-07-15 Canada 
- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 28tak Clair Tooth Silicon dioxide (4.8 g/60g) + Sodium fluorophosphate (0.13 g/60g) Paste, dentifrice Oral Elmeditec Co.,Ltd 2018-07-01 Not applicable US 28tak Doux Tooth Silicon dioxide (4.8 g/60g) Paste, dentifrice Oral Elmeditec Co.,Ltd 2018-07-01 Not applicable US Alegria Neo Silicon dioxide (2.80 g/20g) + Allantoin (0.008 g/20g) Paste, dentifrice Topical Seowangmo Corporation 2017-10-01 Not applicable US Antiseptic Disinfectant Silicon dioxide (0.56 g/100mL) Liquid Topical Nano Care Deutschland AG 2020-03-28 Not applicable US Cheee Gold Plus Tooth Silicon dioxide (7.8 g/130g) + alpha-Tocopherol acetate (0.13 g/130g) Paste, dentifrice Oral Nature Plus 2020-07-01 Not applicable US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- ETJ7Z6XBU4
- CAS number
- 7631-86-9
- InChI Key
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N
- InChI
- InChI=1S/O2Si/c1-3-2
- IUPAC Name
- silanedione
- SMILES
- O=[Si]=O
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0035659
- PubChem Compound
- 22644374
- PubChem Substance
- 347827911
- ChemSpider
- 22683
- 314826
- ChEBI
- 30563
- ChEMBL
- CHEMBL3188292
- Wikipedia
- Silicon_dioxide
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Dental Decay 1 4 Completed Treatment Gastro-esophageal Reflux Disease (GERD) 1 3 Completed Other Caries 1 3 Completed Treatment Enamel Erosion 1 3 Completed Treatment Hypersensitivity Dentin 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Paste, dentifrice Dental 15 g/100g Paste, dentifrice Oral Paste, dentifrice Oral 4.8 g/60g Paste, dentifrice Topical Liquid Topical 0.56 g/100mL Paste Dental Powder Topical 30 g/100g Paste, dentifrice Dental Gel, dentifrice Dental Paste, dentifrice Dental 6 g/100g Paste, dentifrice Dental 8 g/100g Granule, effervescent Oral Powder Topical 20 g/100g Paste Dental 8 g/100g Paste, dentifrice Dental 17 g/100g Powder Topical Tablet, chewable Oral Capsule Oral Paste, dentifrice Topical 15.0 g/100g Paste Oral Paste Oral 170 mg/1g Gel Dental 1.71 g/60g Gel Dental 1.425 g/50g Kit Dental Liquid Oral Emulsion Oral Paste, dentifrice Oral 15.0 g/100g Paste, dentifrice Oral 24.0 g/160g Liquid Topical Capsule Liquid Oral 80 mg / 5 mL Gel Oral 80 mg / 5 mL Capsule Oral Capsule Oral 5 mg / cap Solution / drops Oral Solution Oral 2 g/100mL Stick Topical 0.88 g/11g Powder Topical 51 kg/100kg Paste, dentifrice Dental 2.14 g/100g Paste Topical Capsule, gelatin coated Oral Tablet Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP -0.66 Chemaxon pKa (Strongest Basic) -8.5 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 34.14 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 2.89 m3·mol-1 Chemaxon Polarizability 3.28 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M+H]+ 85.8780421 predictedDarkChem Lite v0.1.0 [M+Na]+ 85.9209421 predictedDarkChem Lite v0.1.0
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.
- Specific Function
- Scavenger receptor activity
- Gene Name
- MARCO
- Uniprot ID
- Q9UEW3
- Uniprot Name
- Macrophage receptor MARCO
- Molecular Weight
- 52657.905 Da
References
- Thakur SA, Hamilton R Jr, Pikkarainen T, Holian A: Differential binding of inorganic particles to MARCO. Toxicol Sci. 2009 Jan;107(1):238-46. doi: 10.1093/toxsci/kfn210. Epub 2008 Oct 4. [Article]
Drug created at December 03, 2015 16:51 / Updated at April 14, 2024 23:45