Reaction: Clozapine to 1 product
- Reaction
- Reaction type
- glucuronidation
- Direction
- Not Available
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Stanbridge AJ, Cranshaw T, Paul MM: Clozapine metabolism may be affected by Gilbert's syndrome: case report and discussion. Pharmacogenet Genomics. 2021 Dec 1;31(9):221-224. doi: 10.1097/FPC.0000000000000444. [Article]
- Pardinas AF, Nalmpanti M, Pocklington AJ, Legge SE, Medway C, King A, Jansen J, Helthuis M, Zammit S, MacCabe J, Owen MJ, O'Donovan MC, Walters JTR: Pharmacogenomic Variants and Drug Interactions Identified Through the Genetic Analysis of Clozapine Metabolism. Am J Psychiatry. 2019 Jun 1;176(6):477-486. doi: 10.1176/appi.ajp.2019.18050589. Epub 2019 Mar 29. [Article]
- Erickson-Ridout KK, Sun D, Lazarus P: Glucuronidation of the second-generation antipsychotic clozapine and its active metabolite N-desmethylclozapine. Potential importance of the UGT1A1 A(TA)(7)TAA and UGT1A4 L48V polymorphisms. Pharmacogenet Genomics. 2012 Aug;22(8):561-76. doi: 10.1097/FPC.0b013e328354026b. [Article]
- Mori A, Maruo Y, Iwai M, Sato H, Takeuchi Y: UDP-glucuronosyltransferase 1A4 polymorphisms in a Japanese population and kinetics of clozapine glucuronidation. Drug Metab Dispos. 2005 May;33(5):672-5. doi: 10.1124/dmd.104.002576. Epub 2005 Feb 11. [Article]
- Breyer-Pfaff U, Wachsmuth H: Tertiary N-glucuronides of clozapine and its metabolite desmethylclozapine in patient urine. Drug Metab Dispos. 2001 Oct;29(10):1343-8. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role UDP-glucuronosyltransferase 1-4 Not Available Not Available implied UDP-glucuronosyltransferase 1-3 Not Available Not Available implied UDP-glucuronosyltransferase 1-1 Not Available Not Available implied UDP-glucuronosyltransferase 2B10 Not Available Not Available implied
