Reaction: Desvenlafaxine to 1 product
- Reaction
- Reaction type
- N-demethylation
- Direction
- Not Available
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- inactive
- References
- Preskorn S, Patroneva A, Silman H, Jiang Q, Isler JA, Burczynski ME, Ahmed S, Paul J, Nichols AI: Comparison of the pharmacokinetics of venlafaxine extended release and desvenlafaxine in extensive and poor cytochrome P450 2D6 metabolizers. J Clin Psychopharmacol. 2009 Feb;29(1):39-43. doi: 10.1097/JCP.0b013e318192e4c1. [Article]
- Holliday SM, Benfield P: Venlafaxine. A review of its pharmacology and therapeutic potential in depression. Drugs. 1995 Feb;49(2):280-94. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 3A4 Not Available Not Available confirmed Cytochrome P450 2C19 Not Available Not Available confirmed Cytochrome P450 2C9 Not Available Not Available implied