Reaction: Desvenlafaxine to 1 product

Reaction
Reaction type
N-demethylation
Direction
Not Available
Major circulating metabolite?
No
Spontaneous?
No
Activity
inactive
References
  1. Preskorn S, Patroneva A, Silman H, Jiang Q, Isler JA, Burczynski ME, Ahmed S, Paul J, Nichols AI: Comparison of the pharmacokinetics of venlafaxine extended release and desvenlafaxine in extensive and poor cytochrome P450 2D6 metabolizers. J Clin Psychopharmacol. 2009 Feb;29(1):39-43. doi: 10.1097/JCP.0b013e318192e4c1. [PubMed:19142106]
  2. Holliday SM, Benfield P: Venlafaxine. A review of its pharmacology and therapeutic potential in depression. Drugs. 1995 Feb;49(2):280-94. [PubMed:7729333]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableconfirmed
Cytochrome P450 2C19Not AvailableNot Availableconfirmed