Reaction: 4-Hydroxytamoxifen to 1 product
- Reaction type
- Major circulating metabolite?
- Poon GK, Chui YC, McCague R, Llnning PE, Feng R, Rowlands MG, Jarman M: Analysis of phase I and phase II metabolites of tamoxifen in breast cancer patients. Drug Metab Dispos. 1993 Nov-Dec;21(6):1119-24. [PubMed:7905393]
- Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
- Not Available
Enzyme Km Vmax Role Cytochrome P450 3A4 Not Available Not Available confirmed Cytochrome P450 2D6 Not Available Not Available confirmed