Reaction: Dronabinol to 1 product

Reaction
Dronabinol
DB00470
9-alpha,10-alpha-epoxyhexahydrocannabinol
DBMET00126
Reaction type
9, 10-epoxidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [Article]
  2. Nasrin S, Watson CJW, Perez-Paramo YX, Lazarus P: Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions. Drug Metab Dispos. 2021 Dec;49(12):1070-1080. doi: 10.1124/dmd.121.000442. Epub 2021 Sep 7. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Prostaglandin G/H synthase 1Not AvailableNot Availableimplied
Cytochrome P450 3A4Not AvailableNot Availableimplied