Reaction: Irinotecan to 1 product
- Reaction
- Reaction type
- hydrolysis
- Direction
- Major circulating metabolite?
- Yes
- Spontaneous?
- No
- Activity
- active
- References
- Ramesh M, Ahlawat P, Srinivas NR: Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives. Biomed Chromatogr. 2010 Jan;24(1):104-23. doi: 10.1002/bmc.1345. [Article]
- Rothenberg ML: Irinotecan (CPT-11): recent developments and future directions--colorectal cancer and beyond. Oncologist. 2001;6(1):66-80. doi: 10.1634/theoncologist.6-1-66. [Article]
- FDA Approved Drug Products: CAMPTOSAR (irinotecan hydrochloride) injection, for intravenous use (January 2022) [Link]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Human Carboxylesterases Not Available Not Available implied
