Reaction: Pioglitazone metabolite M-II to 1 product

Reaction
Reaction type
oxidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
inactive
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [Article]
  2. Jaakkola T, Laitila J, Neuvonen PJ, Backman JT: Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors. Basic Clin Pharmacol Toxicol. 2006 Jul;99(1):44-51. doi: 10.1111/j.1742-7843.2006.pto_437.x. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2C8Not AvailableNot Availableconfirmed
Cytochrome P450 3A4Not AvailableNot Availableconfirmed