Reaction: Apremilast to 1 product

Reaction
Reaction type
O-demethylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
inactive
References
  1. Hoffmann M, Kumar G, Schafer P, Cedzik D, Capone L, Fong KL, Gu Z, Heller D, Feng H, Surapaneni S, Laskin O, Wu A: Disposition, metabolism and mass balance of [(14)C]apremilast following oral administration. Xenobiotica. 2011 Dec;41(12):1063-75. doi: 10.3109/00498254.2011.604745. Epub 2011 Aug 23. [Article]
  2. FDA Approved Drug Products: Otezla (apremilast) tablets for oral use [Link]
  3. Apremilast, pubchem [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableconfirmed
Cytochrome P450 2A6Not AvailableNot Availableimplied
Cytochrome P450 1A2Not AvailableNot Availableimplied