Reaction: Triethylenetetramine to 1 product
- Reaction
- Reaction type
- acetylation
- Direction
- Major circulating metabolite?
- Yes
- Spontaneous?
- No
- Activity
- active
- References
- Cerrada-Gimenez M, Weisell J, Hyvonen MT, Park MH, Alhonen L, Vepsalainen J, Keinanen TA: Complex N-acetylation of triethylenetetramine. Drug Metab Dispos. 2011 Dec;39(12):2242-9. doi: 10.1124/dmd.111.041798. Epub 2011 Aug 30. [Article]
- Kodama H, Murata Y, Iitsuka T, Abe T: Metabolism of administered triethylene tetramine dihydrochloride in humans. Life Sci. 1997;61(9):899-907. [Article]
- Lu J, Poppitt SD, Othman AA, Sunderland T, Ruggiero K, Willett MS, Diamond LE, Garcia WD, Roesch BG, Cooper GJ: Pharmacokinetics, pharmacodynamics, and metabolism of triethylenetetramine in healthy human participants: an open-label trial. J Clin Pharmacol. 2010 Jun;50(6):647-58. doi: 10.1177/0091270009349379. Epub 2010 Feb 9. [Article]
- FDA Approved Drug Products: CUVRIOR (trientine tetrahydrochloride) tablets, for oral use [Link]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Diamine acetyltransferase 1 Not Available Not Available implied
