Reaction: Topiroxostat to 1 product

Reaction
Topiroxostat
DB01685
    Topiroxostat N-oxide
    DBMET01500
    Reaction type
    N-oxidation
    Direction
    Major circulating metabolite?
    Yes
    Spontaneous?
    No
    Activity
    unknown
    References
    1. Matsumoto K, Okamoto K, Ashizawa N, Nishino T: FYX-051: a novel and potent hybrid-type inhibitor of xanthine oxidoreductase. J Pharmacol Exp Ther. 2011 Jan;336(1):95-103. doi: 10.1124/jpet.110.174540. Epub 2010 Oct 15. [Article]
    2. Nakazawa T, Miyata K, Omura K, Iwanaga T, Nagata O: Metabolic profile of FYX-051 (4-(5-pyridin-4-yl-1h-[1,2,4]triazol-3-yl)pyridine-2-carbonitrile) in the rat, dog, monkey, and human: identification of N-glucuronides and N-glucosides. Drug Metab Dispos. 2006 Nov;34(11):1880-6. Epub 2006 Aug 16. [Article]
    Comments
    Not Available
    Enzymes
    Not Available