Reaction: Aripiprazole to 1 product

Reaction
Reaction type
Aromatic hydroxylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Shi, R., Li, W., Liu, G. and Tang, Y.: Catalytic mechanism of Cytochrome P450 2D6 for 4-hyroxylation of aripirazole: A QM/MM study. Chinese Journal of Chemistry. 2013;31:1219–1227. [Article]
  2. Bauman JN, Frederick KS, Sawant A, Walsky RL, Cox LM, Obach RS, Kalgutkar AS: Comparison of the bioactivation potential of the antidepressant and hepatotoxin nefazodone with aripiprazole, a structural analog and marketed drug. Drug Metab Dispos. 2008 Jun;36(6):1016-29. doi: 10.1124/dmd.108.020545. Epub 2008 Mar 10. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2D6Not AvailableNot Availableimplied
Cytochrome P450 3A4Not AvailableNot Availableimplied