Reaction: Astemizole to 2 products

Reaction
Reaction type
N-dealkylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Matsumoto S, Yamazoe Y: Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine. Br J Clin Pharmacol. 2001 Feb;51(2):133-42. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableimplied