Reaction: Lisofylline to 1 product

Reaction
Lisofylline
DB12406
Pentoxifylline
DB00806
Reaction type
N-oxidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Lee SH, Slattery JT: Cytochrome P450 isozymes involved in lisofylline metabolism to pentoxifylline in human liver microsomes. Drug Metab Dispos. 1997 Dec;25(12):1354-8. [Article]
  2. Lillibridge JA, Kalhorn TF, Slattery JT: Metabolism of lisofylline and pentoxifylline in human liver microsomes and cytosol. Drug Metab Dispos. 1996 Nov;24(11):1174-9. [Article]
  3. Shin HS, Slattery JT: CYP3A4-mediated oxidation of lisofylline to lisofylline 4,5-diol in human liver microsomes. J Pharm Sci. 1998 Mar;87(3):390-3. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 1A2Not AvailableNot Availableimplied