Reaction: Caffeine to 1 product

Reaction
Reaction type
3-N-demethylation
Direction
Not Available
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
unknown
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Begas E, Kouvaras E, Tsakalof A, Papakosta S, Asprodini EK: In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios. Biomed Chromatogr. 2007 Feb;21(2):190-200. [PubMed:17221922]
  3. Kot M, Daniel WA: Caffeine as a marker substrate for testing cytochrome P450 activity in human and rat. Pharmacol Rep. 2008 Nov-Dec;60(6):789-97. [PubMed:19211970]
  4. Benowitz NL, Jacob P 3rd, Mayan H, Denaro C: Sympathomimetic effects of paraxanthine and caffeine in humans. Clin Pharmacol Ther. 1995 Dec;58(6):684-91. [PubMed:8529334]
  5. Thorn CF, Aklillu E, McDonagh EM, Klein TE, Altman RB: PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95. doi: 10.1097/FPC.0b013e3283505d5e. [PubMed:22293536]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 1A2Not AvailableNot Availableconfirmed