Reaction: Brigatinib to 1 product

Reaction
Brigatinib
DB12267
AP26123
DBMET01863
Reaction type
N-demethylation; cysteine conjugation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
active
References
  1. Markham A: Brigatinib: First Global Approval. Drugs. 2017 Jul;77(10):1131-1135. doi: 10.1007/s40265-017-0776-3. [Article]
  2. FDA Reports [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2C8Not AvailableNot Availableconfirmed
Cytochrome P450 3A4Not AvailableNot Availableconfirmed