Reaction: Semaglutide to 1 product

Reaction
Semaglutide
DB13928
P3 semaglutide
DBMET01885
Reaction type
hydrolysis; oxidation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
active
References
  1. Jensen L, Helleberg H, Roffel A, van Lier JJ, Bjornsdottir I, Pedersen PJ, Rowe E, Derving Karsbol J, Pedersen ML: Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species. Eur J Pharm Sci. 2017 Jun 15;104:31-41. doi: 10.1016/j.ejps.2017.03.020. Epub 2017 Mar 16. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Dipeptidyl peptidase 4Not AvailableNot Availableconfirmed
NeprilysinNot AvailableNot Availableconfirmed