Reaction: Testosterone undecanoate to 2 products

Reaction
Testosterone undecanoate
DB13946
    Testosterone
    DB00624
    Undecanoate
    DBMET03460
    Reaction type
    esterase hydrolysis
    Direction
    Major circulating metabolite?
    Yes
    Spontaneous?
    No
    Activity
    active
    References
    1. BS DJHMB: Androgen Physiology, Pharmacology and Abuse . [Article]
    2. Ando T, Nishiyama T, Takizawa I, Ishizaki F, Miyashiro Y, Takeda K, Hara N, Tomita Y: Dihydrotestosterone synthesis pathways from inactive androgen 5alpha-androstane-3beta,17beta-diol in prostate cancer cells: Inhibition of intratumoural 3beta-hydroxysteroid dehydrogenase activities by abiraterone. Sci Rep. 2016 Aug 26;6:32198. doi: 10.1038/srep32198. [Article]
    3. Lachance S, Dhingra O, Bernstein J, Gagnon S, Savard C, Pelletier N, Boudreau N, Levesque A: Importance of measuring testosterone in enzyme-inhibited plasma for oral testosterone undecanoate androgen replacement therapy clinical trials. Future Sci OA. 2015 Nov 1;1(4):FSO55. doi: 10.4155/fso.15.55. eCollection 2015 Nov. [Article]
    4. Pirog EC, Collins DC: Metabolism of dihydrotestosterone in human liver: importance of 3alpha- and 3beta-hydroxysteroid dehydrogenase. J Clin Endocrinol Metab. 1999 Sep;84(9):3217-21. doi: 10.1210/jcem.84.9.5963. [Article]
    5. Swerdloff RS, Wang C, White WB, Kaminetsky J, Gittelman MC, Longstreth JA, Dudley RE, Danoff TM: A New Oral Testosterone Undecanoate Formulation Restores Testosterone to Normal Concentrations in Hypogonadal Men. J Clin Endocrinol Metab. 2020 Aug 1;105(8). pii: 5834353. doi: 10.1210/clinem/dgaa238. [Article]
    6. Davey RA, Grossmann M: Androgen Receptor Structure, Function and Biology: From Bench to Bedside. Clin Biochem Rev. 2016 Feb;37(1):3-15. [Article]
    7. FDA Approved Drug Products: AVEED (testosterone undecanoate) injection, for intramuscular use CIII [Link]
    8. FDA Approved Drug Products: TLANDO (testosterone undecanoate) capsules, for oral use, CIII [Link]
    9. FDA Approved Drug Products: JATENZO (testosterone undecanoate) capsules, for oral use CIII [Link]
    Comments
    Not Available
    Enzymes
    Not Available