Reaction: Ibrutinib to 1 product

Reaction
Ibrutinib
DB09053
    PCI-45227 (M37)
    DBMET02022
    Reaction type
    Ring epoxidation; hydrolysis
    Direction
    Major circulating metabolite?
    Yes
    Spontaneous?
    No
    Activity
    active
    References
    1. Scheers E, Leclercq L, de Jong J, Bode N, Bockx M, Laenen A, Cuyckens F, Skee D, Murphy J, Sukbuntherng J, Mannens G: Absorption, metabolism, and excretion of oral (1)(4)C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97. doi: 10.1124/dmd.114.060061. Epub 2014 Dec 8. [Article]
    Comments
    Not Available
    Enzymes
    Not Available