Reaction: Amifampridine to 1 product

Reaction
Amifampridine
DB11640
3-N-acetylamifampridine
DBMET02121
Reaction type
acetylation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
inactive
References
  1. Haroldsen PE, Sisic Z, Datt J, Musson DG, Ingenito G: Acetylator Status Impacts Amifampridine Phosphate (Firdapse) Pharmacokinetics and Exposure to a Greater Extent Than Renal Function. Clin Ther. 2017 Jul;39(7):1360-1370. doi: 10.1016/j.clinthera.2017.05.353. Epub 2017 Jun 19. [Article]
  2. Lindquist S, Stangel M: Update on treatment options for Lambert-Eaton myasthenic syndrome: focus on use of amifampridine. Neuropsychiatr Dis Treat. 2011;7:341-9. doi: 10.2147/NDT.S10464. Epub 2011 May 30. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Arylamine N-acetyltransferase 2Not AvailableNot Availableconfirmed
Arylamine N-acetyltransferase 1Not AvailableNot Availableconfirmed