Reaction: Glasdegib to 1 product

Reaction
Glasdegib
DB11978
Glasdegib M3
DBMET02205
Reaction type
demethylation
Direction
Not Available
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
active
References
  1. Lam JL, Vaz A, Hee B, Liang Y, Yang X, Shaik MN: Metabolism, excretion and pharmacokinetics of [(14)C]glasdegib (PF-04449913) in healthy volunteers following oral administration. Xenobiotica. 2017 Dec;47(12):1064-1076. doi: 10.1080/00498254.2016.1261307. Epub 2017 Jan 3. [Article]
  2. EMA Assessment Report: Daurismo International non-proprietary name glasdegib [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableimplied