Reaction: Oseltamivir to 1 product

Reaction
Oseltamivir
DB00198
Oseltamivir carboxylate
DBMET02218
Reaction type
esterase hydrolysis
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
active
References
  1. Fuke C, Ihama Y, Miyazaki T: Analysis of oseltamivir active metabolite, oseltamivir carboxylate, in biological materials by HPLC-UV in a case of death following ingestion of Tamiflu. Leg Med (Tokyo). 2008 Mar;10(2):83-7. doi: 10.1016/j.legalmed.2007.07.003. Epub 2007 Aug 27. [Article]
  2. Zhu HJ, Markowitz JS: Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants. Drug Metab Dispos. 2009 Feb;37(2):264-7. doi: 10.1124/dmd.108.024943. Epub 2008 Nov 20. [Article]
  3. Oseltamivir EMA Label [File]
Comments
Via hepatic esterases (hydrolases).
Enzymes
EnzymeKmVmaxRole
Liver carboxylesterase 1Not AvailableNot Availableconfirmed