Reaction: Lovastatin to 1 product

Reaction
Lovastatin
DB00227
6'-exomethylene lovastatin
DBMET02237
Reaction type
reduction
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
active
References
  1. Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Benet LZ, Sewing KF, Christians U: Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug Metab Dispos. 1999 Feb;27(2):173-9. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableconfirmed