Reaction: Imatinib to 1 product
- Reaction
- Reaction type
- N-oxidation
- Direction
- Not Available
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Rochat B, Zoete V, Grosdidier A, von Grunigen S, Marull M, Michielin O: In vitro biotransformation of imatinib by the tumor expressed CYP1A1 and CYP1B1. Biopharm Drug Dispos. 2008 Mar;29(2):103-18. doi: 10.1002/bdd.598. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Dimethylaniline monooxygenase [N-oxide-forming] 3 Not Available Not Available implied Cytochrome P450 3A4 Not Available Not Available implied