Reaction: Esketamine to 1 product

Reaction
Esketamine
DB11823
Noresketamine
DBMET02276
Reaction type
N-demethylation
Direction
Not Available
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Peltoniemi MA, Hagelberg NM, Olkkola KT, Saari TI: Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. Clin Pharmacokinet. 2016 Sep;55(9):1059-77. doi: 10.1007/s40262-016-0383-6. [Article]
  2. Ricardo Jorge Dinis-Oliveira (2017). Metabolism and metabolomics of ketamine: a toxicological approach. Taylor & Francis Group.
  3. Spravato FDA label [File]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableconfirmed
Cytochrome P450 2B6Not AvailableNot Availableconfirmed
Cytochrome P450 2C9Not AvailableNot Availableconfirmed
Cytochrome P450 2C19Not AvailableNot Availableimplied