Reaction: Valaciclovir to 2 products

Reaction
Valaciclovir
DB00577
Acyclovir
DBMET02296
L-valine
DBMET02303
Reaction type
Not Available
Direction
Not Available
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Beutner KR: Valacyclovir: a review of its antiviral activity, pharmacokinetic properties, and clinical efficacy. Antiviral Res. 1995 Dec;28(4):281-90. [Article]
  2. Marsillach J, Suzuki SM, Richter RJ, McDonald MG, Rademacher PM, MacCoss MJ, Hsieh EJ, Rettie AE, Furlong CE: Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase. PLoS One. 2014 Oct 15;9(10):e110054. doi: 10.1371/journal.pone.0110054. eCollection 2014. [Article]
  3. Valtrex tablets, MedSafe NZ [File]
  4. FDA label, Valacyclovir [File]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Valacyclovir hydrolaseNot AvailableNot Availableimplied