Reaction: Methylphenidate to 1 product

Reaction
Methylphenidate
DB00422
α-phenyl-2-piperidine acetic acid (ritalinic acid)
DBMET02308
Reaction type
esterase hydrolysis
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
inactive
References
  1. Sun Z, Murry DJ, Sanghani SP, Davis WI, Kedishvili NY, Zou Q, Hurley TD, Bosron WF: Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1. J Pharmacol Exp Ther. 2004 Aug;310(2):469-76. doi: 10.1124/jpet.104.067116. Epub 2004 Apr 13. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
CarboxylesteraseNot AvailableNot Availableconfirmed