Reaction: Siponimod to 7 products

Reaction
Siponimod
DB12371
M1 metabolite, Siponimod
DBMET02330
M17 metabolite, Siponimod
DBMET02333
M2 metabolite, Siponimod
DBMET02331
M5 metabolite, Siponimod
DBMET02328
M6 metabolite, Siponimod
DBMET02327
M7 metabolite, Siponimod
DBMET02329
M8 metabolite, Siponimod
DBMET02332
Reaction type
hydroxylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Glaenzel U, Jin Y, Nufer R, Li W, Schroer K, Adam-Stitah S, Peter van Marle S, Legangneux E, Borell H, James AD, Meissner A, Camenisch G, Gardin A: Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism. Drug Metab Dispos. 2018 Jul;46(7):1001-1013. doi: 10.1124/dmd.117.079574. Epub 2018 May 7. [Article]
  2. Siponimod FDA label [File]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableconfirmed
Cytochrome P450 2C9Not AvailableNot Availableconfirmed