Reaction: Thalidomide to 1 product
- Reaction
- Reaction type
- Ring epoxidation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- active
- References
- Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [Article]
- Lepper ER, Smith NF, Cox MC, Scripture CD, Figg WD: Thalidomide metabolism and hydrolysis: mechanisms and implications. Curr Drug Metab. 2006 Aug;7(6):677-85. doi: 10.2174/138920006778017777. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 1A1 Not Available Not Available confirmed Cytochrome P450 1A2 Not Available Not Available confirmed Cytochrome P450 2C19 Not Available Not Available confirmed Cytochrome P450 2E1 Not Available Not Available confirmed