Reaction: Fluconazole to 1 product

Reaction
Reaction type
glucuronidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Brammer KW, Coakley AJ, Jezequel SG, Tarbit MH: The disposition and metabolism of [14C]fluconazole in humans. Drug Metab Dispos. 1991 Jul-Aug;19(4):764-7. [Article]
  2. Bourcier K, Hyland R, Kempshall S, Jones R, Maximilien J, Irvine N, Jones B: Investigation into UDP-glucuronosyltransferase (UGT) enzyme kinetics of imidazole- and triazole-containing antifungal drugs in human liver microsomes and recombinant UGT enzymes. Drug Metab Dispos. 2010 Jun;38(6):923-9. doi: 10.1124/dmd.109.030676. Epub 2010 Mar 19. [Article]
Comments
It has been suggested that UGT2B7 is primarily responsible for the O-glucuronidation of fluconazole.
Enzymes
EnzymeKmVmaxRole
UDP-glucuronosyltransferase 2B7Not AvailableNot Availableimplied