Reaction: Metronidazole to 1 product

Reaction
Metronidazole
DB00916
2-hydroxymetronidazole
DBMET02624
Reaction type
hydroxylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Pearce RE, Cohen-Wolkowiez M, Sampson MR, Kearns GL: The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst. Drug Metab Dispos. 2013 Sep;41(9):1686-94. doi: 10.1124/dmd.113.052548. Epub 2013 Jun 27. [Article]
  2. Farrell G, Baird-Lambert J, Cvejic M, Buchanan N: Disposition and metabolism of metronidazole in patients with liver failure. Hepatology. 1984 Jul-Aug;4(4):722-6. [Article]
  3. Wang LA, Gonzalez D, Leeder JS, Tyndale RF, Pearce RE, Benjamin DK Jr, Kearns GL, Cohen-Wolkowiez M: Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation. J Clin Pharmacol. 2017 Feb;57(2):230-234. doi: 10.1002/jcph.797. Epub 2016 Aug 23. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableimplied
Cytochrome P450 2A6Not AvailableNot Availableimplied
Cytochrome P450 3A5Not AvailableNot Availableimplied
Cytochrome P450 3A7Not AvailableNot Availableimplied