Reaction: Istradefylline to 1 product

Reaction
Istradefylline
DB11757
    4'-O-monodesmethyl istradefylline (M1)
    DBMET02750
    Reaction type
    O-demethylation
    Direction
    Major circulating metabolite?
    Yes
    Spontaneous?
    No
    Activity
    active
    References
    1. Mukai M, Uchimura T, Zhang X, Greene D, Vergeire M, Cantillon M: Effects of Rifampin on the Pharmacokinetics of a Single Dose of Istradefylline in Healthy Subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201. doi: 10.1002/jcph.1003. Epub 2017 Sep 7. [Article]
    2. Pharmaceuticals and Medical Devices Agency Japan: Report on Istradefylline [Link]
    Comments
    Not Available
    Enzymes
    Not Available