Reaction: Colchicine to 1 product

Reaction
Reaction type
demethylation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
unknown
References
  1. Davis MW, Wason S, Digiacinto JL: Colchicine-antimicrobial drug interactions: what pharmacists need to know in treating gout. Consult Pharm. 2013 Mar;28(3):176-83. doi: 10.4140/TCP.n.2013.176. [Article]
  2. Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ: Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation. Biochem Pharmacol. 1997 Jan 10;53(1):111-6. doi: 10.1016/s0006-2952(96)00693-4. [Article]
  3. Nazia M. Sadiq; Kenneth J. Robinson; Jamie M. Terrell (2019). Colchicine. StatPearls Publishing.
  4. FDA Approved Drug Products: Colcrys (colchicine) tablets for oral use (May 2020) [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableconfirmed