Reaction: Loratadine to 1 product

Reaction
Reaction type
hydoxylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Aratyn-Schaus Y, Ramanathan R: Advances in high-resolution MS and hepatocyte models solve a long-standing metabolism challenge: the loratadine story. Bioanalysis. 2016 Aug;8(16):1645-62. doi: 10.4155/bio-2016-0094. Epub 2016 Jul 27. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 1A1Not AvailableNot Availableimplied
Cytochrome P450 2B6Not AvailableNot Availableimplied
Cytochrome P450 2C8Not AvailableNot Availableimplied
Cytochrome P450 2C9Not AvailableNot Availableimplied
Cytochrome P450 2C19Not AvailableNot Availableimplied
Cytochrome P450 2D6Not AvailableNot Availableimplied
Cytochrome P450 3A4Not AvailableNot Availableimplied
Cytochrome P450 3A5Not AvailableNot Availableimplied