Reaction: Anastrozole to 1 product

Reaction
Anastrozole
DB01217
    Triazole
    DBMET02828
    Reaction type
    N-dealkylation
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    inactive
    References
    1. Kamdem LK, Liu Y, Stearns V, Kadlubar SA, Ramirez J, Jeter S, Shahverdi K, Ward BA, Ogburn E, Ratain MJ, Flockhart DA, Desta Z: In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole. Br J Clin Pharmacol. 2010 Dec;70(6):854-69. doi: 10.1111/j.1365-2125.2010.03791.x. [Article]
    2. FDA Approved Drug Products: Arimidex (anastrozole) oral tablets [Link]
    Comments
    Triazole (a product of N-dealkylation of anastrozole) has long been considered a major circulating metabolite as per anastrozole's label. Follow-up studies on anastrozole metabolism (Kamdem, et. al. 2010) have failed to detect it in plasma, so the importance of triazole as a metabolite, as well as the process through which it is created, are unclear.
    Enzymes
    Not Available