Reaction: Tretinoin to 1 product

Reaction
Reaction type
Ring epoxidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Marill J, Idres N, Capron CC, Nguyen E, Chabot GG: Retinoic acid metabolism and mechanism of action: a review. Curr Drug Metab. 2003 Feb;4(1):1-10. doi: 10.2174/1389200033336900. [Article]
  2. Marill J, Cresteil T, Lanotte M, Chabot GG: Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. [Article]
  3. Regazzi MB, Iacona I, Gervasutti C, Lazzarino M, Toma S: Clinical pharmacokinetics of tretinoin. Clin Pharmacokinet. 1997 May;32(5):382-402. doi: 10.2165/00003088-199732050-00004. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2C8Not AvailableNot Availableimplied
Cytochrome P450 2C9Not AvailableNot Availableimplied
Cytochrome P450 1A1Not AvailableNot Availableimplied
Cytochrome P450 2A6Not AvailableNot Availableimplied
Cytochrome P450 2B6Not AvailableNot Availableimplied
Cytochrome P450 3A4Not AvailableNot Availableimplied
Cytochrome P450 3A5Not AvailableNot Availableimplied