Reaction: Isosorbide mononitrate to 1 product
- Reaction
- Reaction type
- Not Available
- Direction
- Major circulating metabolite?
- Yes
- Spontaneous?
- No
- Activity
- active
- References
- Munzel T, Steven S, Daiber A: Organic nitrates: update on mechanisms underlying vasodilation, tolerance and endothelial dysfunction. Vascul Pharmacol. 2014 Dec;63(3):105-13. doi: 10.1016/j.vph.2014.09.002. Epub 2014 Oct 14. [Article]
- Kenkare SR, Benet LZ: Tolerance to nitroglycerin in rabbit aorta. Investigating the involvement of the mu isozyme of glutathione S-transferases. Biochem Pharmacol. 1996 May 17;51(10):1357-63. doi: 10.1016/0006-2952(96)00058-5. [Article]
- Comments
- Based on the findings of several studies, isosorbide mononitrate is bioactivated by hepatic CYP P450 enzymes, xanthine oxidoreductase (XO), mu isozyme of glutathione-S-transferase (GST), or cytosolic aldehyde dehydrogenase isoforms (cytALDH = 1A1, 3A1 or cytosolic ALDH-2).[A190732]
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 3A Subfamily Not Available Not Available implied Glutathione S-transferase Mu 1 Not Available Not Available implied Xanthine dehydrogenase/oxidase Not Available Not Available implied Alcohol dehydrogenase class-3 Not Available Not Available implied
