Reaction: Lopinavir to 1 product

Reaction
Lopinavir
DB01601
    Lopinavir M3/M4 metabolite(s)
    DBMET03070
    Reaction type
    oxidation
    Direction
    Major circulating metabolite?
    Yes
    Spontaneous?
    No
    Activity
    unknown
    References
    1. Kumar GN, Jayanti V, Lee RD, Whittern DN, Uchic J, Thomas S, Johnson P, Grabowski B, Sham H, Betebenner D, Kempf DJ, Denissen JF: In vitro metabolism of the HIV-1 protease inhibitor ABT-378: species comparison and metabolite identification. Drug Metab Dispos. 1999 Jan;27(1):86-91. [Article]
    Comments
    The M3 and M4 metabolites, major metabolic products of lopinavir, are thought to both be epimers of the same 4-hydroxy lopinavir molecule.
    Enzymes
    Not Available