Reaction: Lopinavir to 1 product

Reaction
Reaction type
oxidation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
unknown
References
  1. Kumar GN, Jayanti V, Lee RD, Whittern DN, Uchic J, Thomas S, Johnson P, Grabowski B, Sham H, Betebenner D, Kempf DJ, Denissen JF: In vitro metabolism of the HIV-1 protease inhibitor ABT-378: species comparison and metabolite identification. Drug Metab Dispos. 1999 Jan;27(1):86-91. [PubMed:9884314]
Comments
The M3 and M4 metabolites, major metabolic products of lopinavir, are thought to both be epimers of the same 4-hydroxy lopinavir molecule.
Enzymes
Not Available