Reaction: Azathioprine to 1 product

Reaction
Azathioprine
DB00993
6-Mercaptopurine
DBMET00630
Reaction type
reduction
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
active
References
  1. Dubinsky MC: Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol. 2004 Sep;2(9):731-43. [Article]
  2. Stocco G, Pelin M, Franca R, De Iudicibus S, Cuzzoni E, Favretto D, Martelossi S, Ventura A, Decorti G: Pharmacogenetics of azathioprine in inflammatory bowel disease: a role for glutathione-S-transferase? World J Gastroenterol. 2014 Apr 7;20(13):3534-41. doi: 10.3748/wjg.v20.i13.3534. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Glutathione S-transferase Mu 1Not AvailableNot Availableconfirmed
Glutathione S-transferase A1Not AvailableNot Availableconfirmed
Glutathione S-transferase A2Not AvailableNot Availableconfirmed